2024年5月9日 · We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box–binding protein 1 (IRE1α/XBP1). Proinflammatory cytokine IL-23 selectively stimulated IRE1α/XBP1 in mouse ILC3s through mitochondrial ROS (mtROS).

2021年10月20日 · We evaluated the therapeutic effect of XBP1 silencing on AOM-DSS model. To selectively target XBP1 in macrophages, sgRNA-Xbp1 adeno-associated virus was produced as described in methods.

XBP1 yields two isoforms: unspliced XBP1 (XBP1-u) and spliced XBP1 (XBP1-s). Upon exposure to endoplasmic reticulum (ER) stress, XBP1-u is spliced, and the 26 nucleotides located between +541 and +566 of XBP1-u are excised, causing a codon frameshift in XBP1-s and distinct C-terminal regions between the two isoforms ( 11 , 12 ).

2008年9月5日 · We show that induction of ER stress in intestinal epithelium through tissue- (and cell type-) specific disruption of Xbp1 results in spontaneous enteritis due to inability of Xbp1 -deficient IECs to properly generate antimicrobial activity and respond appropriately to inflammatory signals in the local milieu.

2015年6月18日 · Here we show that constitutive activation of XBP1 in tumor-associated DCs (tDCs) drives ovarian cancer (OvCa) progression by blunting anti-tumor immunity.

2022年1月1日 · Our data suggest a crucial role for XBP1 in coordinating epithelial DNA damage responses and stem cell function via a p53-DDIT4L–dependent feedback mechanism. The inflammatory bowel disease risk gene X-box protein 1 essentially coordinates epithelial cell function and thereby contributes to intestinal mucosal homeostasis.

Univariate and multivariate analyses revealed that XBP1 expression, tumor differentiation, vascular invasion, tumor stage, and the rate of recurrence were linked to DSS, while low cytoplasmic XBP1 expression remained an independent predictor of poor DSS.

X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation ...

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress ...

2020年5月9日 · miR-330-3p is upregulated by DSS in both HT-29 cells and mice and promoted ulcerative colitis and cell apoptosis by targeting of 3'-UTR of XBP1, which is a key component of ER stress. Inhibition of miR-330-3p prevent DSS-induced ulcerative colitis and cell apoptosis mediated by upregulation of XBP1 …