Roles of XBP1s in Transcriptional Regulation of Target Genes
2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic …
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
2022年3月24日 · We show that Pumilio protects Drosophila Xbp1 against RIDD, without perturbing canonical Ire1-driven Xbp1 splicing. Furthermore, we provide evidence that Ire1 …
IRE1α–XBP1 safeguards hematopoietic stem and progenitor
2025年1月9日 · Here, we uncover unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells (HSPCs) as a …
XBP1: a link between the unfolded protein response, lipid …
In response to increased demand on the protein folding capacity of the ER, UPR-mediated splicing of XBP1 mRNA yields the XBP1(S) transcriptional activator. We propose that XBP1(S) …
UAS-Xbp1-GFP - Addgene
Plasmid UAS-Xbp1-GFP from Dr. Herman Steller's lab contains the insert Xbp1 and is published in EMBO J. 2007 Jan 10;26(1):242-52. Epub 2006 Dec 14. This plasmid is available through …
Constitutive XBP-1s-mediated activation of the endoplasmic
2019年9月30日 · IRE1α catalyzes non-canonical splicing of X-box binding protein 1 (XBP1) mRNA into the constitutively active form XBP1s, which becomes the master UPR ER …
Drosophila XBP1 Expression Reporter Marks Cells under ... - PLOS
2013年9月30日 · Here, we report that the XBP1 promoter activity itself is enhanced in secretory tissues of Drosophila, and it can be induced by excessive ER stress. Specifically, we …
XBP1 Controls Diverse Cell Type- and Condition-Specific ... - Cell …
2007年7月6日 · To identify tissue- and condition-specific XBP1 target genes, we analyzed five cell populations, including skeletal muscle myotubes, myotubes treated with 2-deoxy-D-glucose …
Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO …
Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic …
Plasma cell differentiation and the unfolded protein response
2003年3月3日 · Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1 −/− mouse B …