XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic …

2025年1月22日 · Using murine genetic models and targeted spatial transcriptomics, we found that the CD8+ T cell-derived chemokine XCL1 is critical for TRM formation and conventional DC1 (cDC1) supported the positioning of intestinal CD8+ T cells during acute viral infection.

The XCL1-specific receptor, XCR1, is a member of the G-protein-coupled receptor family and plays an important role in the negative selection of T cells in the thymus and in the initiation of cross-antigen presentation and mediation of cytotoxic immune responses.

2020年3月2日 · Through immunohistochemistry analysis, we identified XCL1 expression on tumor cells in 13/24 (54%) of MCT-SCCs but not in MCTs. XCL1 expression was also significantly associated with the...

2025年1月6日 · On interaction with CT26.CEA-positive cells, 7XCL1-CAR T cells secreted higher levels of XCL1 and IL-7, effectively recruited the most potent cross-presenting cDC1s (type-I conventional dendritic cells), and sustained the antitumor activity of CAR-T cells.

XCL1 signals through XCR1 and is a chemoattractant for T cells and NK cells in vitro and in vivo. XCL1 can induce anti-tumor immunity in mice synergy with IL-2. There is also evidence that XCL1 may have a role in graft rejection and T-cell-mediated autoimmunity and as a vaccine adjuvant.

2016年3月23日 · Activated intestinal T cells produce XCL1, which attracts nearby XCR1 + DC; the ensuing DC-T cell crosstalk supports T cell survival, promotes upregulation of CD103 expression with...

2017年2月21日 · We found that pDCs accumulated at sites of CD8 + T cell antigen-driven activation in a CCR5-dependent fashion. Furthermore, activated CD8 + T cells orchestrated the local recruitment of lymph node-resident XCR1 chemokine receptor-expressing DCs via secretion of the XCL1 chemokine.

1 天前 · We also observed a population of naïve CD4 T cells (denoted ‘Xcl1 + naïve’) expressing Lef1 and Sell genes along with Xcl1, which is a ligand of XCR1 (or G protein-coupled receptor 5, GPR5), with increased expression on NK and CD8 + T cells during virus infection.

In the cell co-culture system, the 7XCL1-CAR T cells exhibited cytotoxicity, secreted both IL-7 and XCL1 on interaction with CEA-positive CRC cells. The XCL1 secreted from 7XCL1-CAR T cells was confirmed to recruit the migratory cDC1s, which promoted the generation of antigen-specific CD8 + T cells, and IL-7 was confirmed to maintain the ...