XCR1 is also known as GPR5. The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor.

2024年12月25日 · XCR1 (X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with XCR1 include Covid-19 and Epilepsy, Familial Adult Myoclonic, 7. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2016年3月23日 · We showed that mice lacking XCR1 + DCs are specifically deficient in intraepithelial and lamina propria (LP) T cell populations, with remaining T cells exhibiting an atypical phenotype and being...

2012年2月9日 · Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human.

在本报告中，我们证明了XCR1仅在鼠CD8 + 树突状细胞（DC）上表达，并表明XCL1是该DC子集的有效且高度特异性的化学引诱剂。 在体内CD8 + DC上抗原识别后的8–36小时内，CD8 + T细胞会大量分泌XCL1 ，在此期间，会发生稳定的T细胞-DC相互作用。 在功能上，XCL1增加了抗原特异性CD8 + T细胞的库及其分泌IFN-γ的能力。 XCL1的缺乏削弱了对CD8 + 交叉呈递的抗原的细胞毒性的发展 DC。 因此，XCL1-XCR1轴成为体内有效细胞毒性免疫发展过程中不可或缺的组 …

XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.

2021年5月20日 · Genetic deletion of XCR1 + cDC1 prevented NASH-associated changes in immune composition in the liver and liver damage, whereas partial blockade of cDC1 infiltration to the liver in advanced NASH...

2021年5月23日 · 进一步的研究显示，在XCR1 DTA 小鼠中给予cDC1或在NASH小鼠模型中采用抗XCL1阻断抗体可减轻肝脏的相关疾病。 总而言之， 该研究结果揭示了NASH中cDC的生物学全面表征，并将XCR1+cDC1鉴定为肝脏相关疾病的重要驱动因素。 原始出处： Deczkowska, A., David, E., Ramadori, P. et al. XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. Nat Med (20 May 2021). 本网站所有内容来源注明为“梅斯医学” …

XCL1 is known as lymphotactin, single C motif-1 (SCM-1), and activation-induced T-cell-derived and chemokine-associated molecule (ATAC) [110]. XCL1 is expressed on various immune cells, including activated CD8 + and CD4 + T cells, NK, NKT, γ δ …

XCR1 [chemokine (C motif) receptor 1] is the only member of chemokine C receptor family. Recently, some studies showed that the interaction between XCR1 and its ligand play an...