异嗜性鼠白血病病毒相关病毒 (XMRV) 是一种逆转录病毒，于 2006 年首次被描述为一种明显的新型人类病原体，在男性QLX癌的组织样本中发现。 最初的报告错误地将该病毒与QLX癌联系起来，后来又与慢性疲劳综合征 (CFS) 联系起来，这引起了科学界和患者社区的极大兴趣，调查了 XMRV 作为多种医疗状况的潜在原因，以及公众对安全性的担忧。 异嗜性病毒在宿主物种以外的细胞中复制或繁殖。 鼠是指鼠科动物，包括常见的家鼠和老鼠。 随后的研究确定 XMRV 实际上 …

2011年4月21日 · Unlike other human pathogenic/oncogenic viruses such as human T cell leukemia virus (HTLV-1) or human papilloma virus (HPV) (Table 1), there is currently no conclusively reproducible epidemiological link for an XMRV-related human disease (prostate cancer or CFS) or a natural XMRV reservoir in humans, mice or other animals (Figure 1).

Inspection of XMRV and HTLV sequences revealed a high level of conservation within the immunodominant region (IDR) of the transmembrane protein. In some cases, HTLV IDR peptide competitively reduced the XMRV p15E signal.

2010年3月10日 · XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus that has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.

2011年10月24日 · The elevated seroreactivity in HTLV-I–infected donors was due to an increased p15E seroreactive rate (4.1%). Inspection of XMRV and HTLV sequences revealed a high level of conservation within the immunodominant region (IDR) of the transmembrane protein. In some cases, HTLV IDR peptide competitively reduced the XMRV p15E signal.

2011年11月1日 · The xenotropic murine leukaemia virus-related virus (XMRV), a gammaretrovirus, was discovered in prostate cancer tumours by Virochip technology in 2006. It was subsequently detected in chronic fatigue patients in 2009. The association between XMRV and chronic fatigue has proved to be controversial.

Results: Of the 291 patients suspected of HTLV infection, 123 (42.3%) were male with a mean age of 38±15 years. HTLV-1 RNA was found in 93 (31.9%) specimens comprising 40 men (41.3%) and 53 women (56.9%). Of the 93 patients who were HTLV-1 positive, one sample (1%) was positive for XMRV env gene.

The recently described XMRV (xenotropic murine leukemia virus-related virus) appeared to possess many of the features known for HTLV and was regarded by some to be the third human retrovirus. However, recent publications by Knox et al. and Paprotka et al. have shed new light on this gammaretrovirus.

2010年3月30日 · XMRV env pseudotyped particles, as well as replication competent XMRV, show a typical xenotropic host range infecting feral mouse cells, all types of human cells tested and several non-rodent species.

Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus, which has been detected in patients with prostate cancer, chronic fatigue syndrome, and general population with a number of acquired infections such as infection with human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus (HIV).