2019年3月21日 · Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins. Proper tuning of protein levels under...

2025年2月9日 · Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication.

2024年12月25日 · XRN1 (5'-3' Exoribonuclease 1) is a Protein Coding gene. Diseases associated with XRN1 include Murray Valley Encephalitis and Osteogenic Sarcoma. Among its related pathways are Autodegradation of the E3 ubiquitin ligase …

Learn more about the different RNases offered by NEB. XRN-1 is highly processive 5´→3´ exoribonuclease, requiring 5´ monophosphate. It also acts on 5´ monophosphate ssDNA with greatly reduced efficiency. Purified from E. coli carrying a …

The recent structure of Rat1 (Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain, defining the active site of the enzyme. Xrn1 has a 510-residue segment following the conserved regions that is required for activity but is absent in Rat1.

2022年2月16日 · Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5′-end exoribonuclease Xrn1 is also a NAD cap decapping (deNADding) enzyme that releases intact NAD and subsequently degrades the...

2013年6月1日 · Cases highlight exciting Drosophila XRN1, human XRN2, and plant XRN4 functions. The XRN family of 5′ → 3′ exoribonucleases is critical for ensuring the fidelity of cellular RNA turnover in eukaryotes.

Cellular 5′-3′ exoribonuclease 1 (XRN1) is best known for its role as a decay factor, which by degrading 5′ monophosphate RNA after the decapping of DCP2 in P-bodies (PBs) in Drosophila, yeast, and mammals. XRN1 has been shown to degrade host ...

2021年10月10日 · In this study, we established a knockout mouse model to investigate the physiological function of XRN1. We provide evidence that a lack of XRN1 in neurons leads to obesity accompanied by leptin resistance, hyperglycemia, hyperinsulinemia, hyperleptinemia, hyperphagia, and decreased energy expenditure in mice.

Xrn1 is a ∼175 kDa processive exoribonuclease that is conserved from yeast to mammals (Johnson and Kolodner, 1991; Stevens, 2001). Xrn1 activity requires divalent metal ions and generates nucleoside monophosphates as products (Stevens, 1980).