Xist (X-inactive specific transcript) is a non-coding RNA transcribed from the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. [5] It is a component of the Xic – X-chromosome inactivation centre [6] – along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2). [7]

2024年12月25日 · XIST (X Inactive Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with XIST include X Inactivation, Familial Skewed, 1 and Collecting Duct Carcinoma.

Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and male (XY) mammals.

2015年8月15日 · We discuss recent advances in our knowledge of Xist-mediated silencing, focusing on Xist spreading, the nuclear organization of the inactive X chromosome, recruitment of the polycomb complex and the role of the nuclear matrix in the process of …

In this manuscript, we summarize the current knowledge about the mechanisms for XIST -mediated XCI and the roles of XIST in sex-biased diseases, and discuss potential therapeutic strategies targeting XIST. Keywords: Epigenetic regulation, Long noncoding RNA, Sex-biased diseases, X chromosome inactivation, XIST.

2024年1月4日 · We found that XIST spreads across the X chromosome and induces dampening of X-linked gene expression in naive hPSCs. Surprisingly, XIST also targets specific autosomal regions, where it induces repressive chromatin changes and gene expression dampening.

Xist is among the first regulatory RNAs discovered and implicated in formation of the inactive X chromosome (Xi). This review focuses on the analysis of Xist function and its molecular mechanism as an important model for functional RNAs.

Xist encodes an RNA molecule that plays critical roles in the choice of which X chromosome remains active, and in the initial spread and establishment of silencing on the inactive X chromosome.

2021年12月7日 · A recent study proposes a refined model, in which Xist transcripts seed giant protein complexes to enable progressive chromatin compaction and expansion of gene silencing.

2024年6月4日 · We show that XIST triggers the deposition of polycomb-mediated repressive histone modifications and dampens the transcription of most X-linked genes in a SPEN-dependent manner, while XACT...