Y79 is a multicellular cluster cell line that was isolated from the retina of a two-and-a-half-year-old, White, female with Retinoblastoma. The donor had a strong maternal family history of retinoblastoma.

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

y79细胞源自一名年仅两岁半的白人女性患者的右眼切除肿瘤组织，患者有视网膜母细胞瘤的家族遗传背景。 Y79细胞系显示出多倍体特征，表现为双着丝粒、断裂、粉碎及分钟体等异常。

2021年8月21日 · We identified a population of large-sized Y79 cells (i.e., giant cells, ~ 40-µm diameter), hyperpolarized resting membrane potential (-54 mV), and low input resistance (~ 600 MΩ), indicating electrically mature cells. We also found that giant Y79 cells contain increased density of T-type calcium channels.

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Y79是一种多细胞簇细胞系，从患有视网膜母细胞瘤的两岁半的白人女性视网膜中分离出来。 提供者具有强烈的视网膜神经胶质瘤母系家族史。 据报道，其超微结构特征包括核膜折叠，三联膜结构，微管，大型被膜囊泡，中心粒、基体和环孔片层等与原始肿瘤类似。 细胞在本库通过支原体检测阴性（可供检测报告）。 细胞在本库通过STR检测无误（可供检测报告）。 RPMI 1640培养基 (GIBCO货号：11875093)，80%；优质胎牛血清，20%。 气相：空气，95%；二氧化碳，5% …

Cells Online offers Human Retinoblastoma Cells (Y79) among many other quality cell lines and primary cells for drug discovery and biomedical research.

In total, 524 transcripts were differentially expressed in Y79/EDR cells based on analysis of fragments per kilobase of transcript per million fragments mapped (FPKM); among these, 57 genes were downregulated and 467 genes were upregulated in Y79/EDR cells compared to parental Y79 cells.

2021年8月15日 · Our data reveals that Y79 cells contain a small fraction of large-sized cells that display the hyperpolarized resting membrane potential and lower input resistance. Notably, these giant Y79 cells exhibited two important features: (1) increased density of T-type calcium channels and (2) a sustained calcium influx at the resting potential.

2024年10月1日 · Through the application of cellular imaging and flow cytometry techniques, the PL3 peptide exhibited a rapid and specific internalization within Y79 cells, with subsequent translocation to the cell nuclei, showcasing notable accumulation in the nucleoli.