2018年2月16日 · Here we demonstrate that the deubiquitination enzyme USP9X deubiquitinates and stabilizes YAP1, thereby promoting cancer cell survival. Increased USP9X expression correlates with increased YAP1...

2020年8月4日 · Tumor necrosis factor receptor-associated factor 6 (TRAF6), a downstream effector of interleukin-1β (IL-1β), triggers YAP ubiquitination at K252, which interrupts the interaction between YAP and angiomotin and results in enhanced YAP nuclear translocation.

2023年2月2日 · In supratentorial hemispheric YAP1–MAMLD1 fusion-positive ependymoma (ST-EPN-YAP1) stem cells, YAP fusion proteins form nuclear condensates through NLS-mediated translocation to the nucleus and...

2022年10月21日 · We discovered OTUB1 as a critical factor to facilitate gastric cancer cell stemness and progression, which deubiquitinated and stabilized YAP protein. The clinical data analysis implicated OTUB1...

2019年8月8日 · Here we report that the E3 ubiquitin ligase STUB1 ubiquitinates and destabilizes YAP1, thereby inhibiting cancer cell survival. Low levels of STUB1 expression were correlated with increased protein levels of YAP1 in human gastric cancer cell lines and patient samples.

2025年2月1日 · Mechanistically, we found that USP14 could interact with Yes-associated protein 1 (YAP1) and induce its deubiquitination in radioresistant ESCA cells. Interestingly, we discovered that DGS/X-ray co-therapy significantly reduced the stability of YAP1 and induced its ubiquitination in radioresistant ESCA cells.

2023年8月2日 · 在这项研究中，作者全面分析了去泛素化酶 (DUB) 对肝细胞癌模型中YAP/TAZ转录活性和蛋白质丰度的贡献，并确定了泛素特异性肽酶10 (USP10) 作为有效的YAP/TAZ激活DUB。 从机制上讲，USP10通过恢复它们的蛋白水解泛素化直接与YAP/TAZ相互作用并稳定它们。 USP10的敲低增强了YAP/TAZ的多泛素化，促进了它们的蛋白酶体降解，并最终在体外和体内阻止了肝细胞癌的增殖。 USP10的表达水平与肝细胞癌患者样本以及亚硝基二乙胺 (DEN) 诱 …

2016年7月7日 · We find that RASSF1A expression regulates TGF-β-induced YAP1/SMAD2 interaction and leads to SMAD2 cytoplasmic retention and inefficient transcription of TGF-β targets genes. Moreover, RASSF1A limits TGF-β induced invasion, offering a new framework on how RASSF1A affects YAP1 transcriptional output and elicits its tumor-suppressive function.

Because hyperactivated YAP1 can promote the occurrence and progress of tumor, YAP1 was defined as an oncoprotein. Recently, researchers found that YAP1 variants were associated with survival rates of small-cell lung cancer patients. YAP1 interacted with catenin and Kras to regulate infiltration and metastasis of cancer cell.

Yap1过表达在非小细胞肺癌（non-smallcelllung cancer，NSCLC）、肝细胞肝癌、胃癌、结直肠癌、小细胞 肺癌等多种肿瘤中是预后差的标志[10]。在临床前研究 中，抑制Yap1可减少肿瘤进展、恢复化疗药物敏感性， Yap1有望成为新的治疗靶点[6]。最近，肿瘤免疫治疗方