YAP-mediated mechanotransduction regulates osteogenic and adipogenic ...
2017年4月1日 · Our study showed that BMSCs seeded on MNT substrates exhibited higher YAP level and promoted YAP nuclear translocation and YAP transcriptional activity, which resulted …
YAP promotes osteogenesis and suppresses adipogenic
2018年6月1日 · Expression of β-catenin in YAP-deficient BMSCs (bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important …
Harnessing matrix stiffness to engineer a bone marrow niche for ...
2023年4月6日 · Here, we show that matrix stiffness fine-tunes HSC niche factor expression by bone marrow stromal cells (BMSCs). Increased stiffness activates Yap/Taz signaling to …
The Hippo-YAP/TAZ-TEAD axis promotes multipotency in bone …
2024年5月17日 · The mechanisms by which bone marrow stromal cells (BMSCs) maintain multilineage potency in vitro remain elusive. To identify the transcriptional regulatory circuits …
YAP介导的机械转导调节BMSCs的成骨和成脂分化 ... - X-MOL
进一步消除细胞骨架张力可抑制YAP功能，这证实了YAP介导的机械转导在BMSC分化中的关键作用。 这些结果共同提供了有关干细胞命运在分层结构上的承诺的信息，以及通过关注特定的 …
The Hippo-YAP/TAZ-TEAD axis promotes multipotency in bone
2024年5月17日 · By computationally reconstructing the regulatory programs associated with initial stages of differentiation and early expansion, we identified the TEAD family of transcription …
AMOT130/YAP pathway in topography-induced BMSC …
2019年10月1日 · To test this, we analyzed cell functions, AMOT130 expression, and YAP intracellular distribution of rat bone marrow mesenchymal stem cells (BMSCs) cultured on Ti …
BMSC-Derived Small Extracellular Vesicles Induce Cartilage
2021年4月1日 · Bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (BMSC-sEVs) may represent a safer and more effective treatment, but their role in TMJOA …
YAP介导的机械转导调节BMSCs在成层结构上的成骨和成脂分化。
进一步消除细胞骨架张力可抑制YAP功能，这证实了YAP介导的机械转导在BMSC分化中的关键作用。 这些结果共同提供了有关干细胞命运在分层结构上的承诺的信息，以及通过关注特定的 …
Pharm Biol：六味地黄丸通过YAP-自噬轴延缓骨髓间充质干细胞 (BMSC…
2023年12月21日 · LWDH上调OVX-BMSCs中自噬相关蛋白LC3、Beclin1和YAP的表达，下调p62的表达。 结论：该研究 首次证明YAP诱导的自噬改变是LWDH延缓OVX中骨髓间充质干 …