2019年6月18日 · YAP and TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here, we show that the ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed in the G2/M phase of the cell cycle.

2014年7月3日 · The Yap1/Tead2 complex acts cooperatively with E2F transcription factors to activate a cell cycle and DNA replication program. Our studies, along with corroborating evidence from human PDAC models, portend a novel mechanism of escape from oncogenic Kras addiction in …

2024年7月15日 · Moreover, emerging evidence suggest that YAP/TAZ interacts with several nuclear factors including E2F, activator protein-1 (AP-1) and bromodomain containing protein 4 to synergistically promote...

2020年3月19日 · IPA analysis of upstream networks affected by siKLF4 indicated an activation of transcriptional targets of MITF, E2F factors and YAP1 (Fig. 3h), confirming that reduction in KLF4 levels leads to...

Functional studies established the role of Yap1 and the transcriptional factor Tead2 in driving Kras G12D -independent tumor maintenance. The Yap1/Tead2 complex acts cooperatively with E2F transcription factors to activate a cell cycle and DNA replication program.

2015年3月17日 · Increased or decreased YAP activity reprograms subsets of hepatocytes to different fates associated with deregulation of the HNF4A, CTNNB1, and E2F transcriptional programs that control hepatocyte quiescence and differentiation.

2015年1月30日 · We found, using siRNA-mediated knockdown, that YAP is required for proliferation in endothelial cells but not HeLa cells. Specifically, YAP is required for S-phase entry and its absence causes cells to accumulate in G1.

YAP induces E2F and AP-1-mediated cell cycle and EMT transcriptional programs to promote survival following ablation of oncogenic Kras in pancreatic and colon cancer cells. Additionally, YAP/TAZ induce EGFRi resistance by increasing the expression of AXL, ERBB3 and EGFR.

Previous studies have shown that E2F and MYC transcription factors are critical regulators of YAP-induced cell-cycle gene activation. For example, YAP and E2F co-regulate cell-cycle genes in the liver (Ehmer et al., 2014).

2023年7月17日 · Mechanistically, ROR1 induces the expression of Aurora kinase B (AURKB) by activating E2F through c-Myc to enhance PDAC proliferation. Furthermore, epigenomic analyses reveal that ROR1 is transcriptionally dependent on YAP/BRD4 binding at the enhancer region, and targeting this pathway reduces ROR1 expression and prevents PDAC growth.