During M2 macrophage polarization, YY1 formed an LLPS, in which p300, p65, and CEBPB acted as transcriptional cofactors. Conclusions: Phase separation of the YY1 complex in M2 macrophages upregulated IL-6 by promoting IL-6 enhancer-promoter interactions, thereby increasing PCa progression.

Our results demonstrated that the secretion of exosomes enriched with hsa-circ-0000326 by YY1-overexpressing M2 macrophages contributes to PCa metastasis. Hsa-circ-0000326 functions as a competitive endogenous RNA against miR-338-3p to promote androgen receptor levels in …

2023年4月1日 · 使用 m2 靶向肽修饰的脂质体载体靶向 m2 巨噬细胞上的 yy1 治疗可抑制 pca 细胞肺转移，并与 pd-1 阻断产生协同抗肿瘤作用。il-4/stat6 通路调节 yy1，yy1 通过上调 il-6 增加巨噬细胞诱导的 pca 进展。此外，通过在m2巨噬细胞和thp-1中进行h3k27ac-c

The transcription factor YY1 is significantly upregulated in M2 macrophages, which can facilitate the malignant progression of multiple cancers. However, the precise mechanisms underlying the influence of YY1-high M2 macrophages on prostate cancer (PCa) progression remain elusive.

综合三部分可以得出结论：前列腺癌组织中yy1和cd163表达正相关，yy1通过激活jak2/stat3通路诱导m2极化；在m2细胞中yy1通过形成复合体结合到il-6的超级增强子和启动子促进il-6的转录和表达，在前列腺癌中il-6通过激活jak2/stat3通路促进前列腺癌进展。

2022年8月1日 · YY1 overexpression could promote M2 polarization of microglia, and alleviate neuroinflammation and behavioral deficits in vitro and in vivo. YY1 could inhibit miR-130a-3p promoter activity. As expected, miR-130a-3p overexpression abolished the effects of YY1 overexpression on LPS-treated BV-2 cells.

综合三部分可以得出结论：前列腺癌组织中yy1和cd163表达正相关，yy1通过激活jak2/stat3通路诱导m2极化；在m2细胞中yy1通过形成复合体结合到il-6的超级增强子和启动子促进il-6的转录和表达，在前列腺癌中il-6通过激活jak2/stat3通路促进前列腺癌进展。

Herein, we demonstrated the role of YY1 in M2 macrophages in transgenic mice overexpressing YY1 and investigated the therapeutic potential of targeting M2 macrophage YY1 to treat prostate cancer (PCa).

2024年3月27日 · 本研究通过过表达yy1的转基因小鼠证明了yy1在m2巨噬细胞中的作用，并研究了靶向m2巨噬细胞yy1治疗前列腺癌（pca）的潜力。 此外，YY1通过调节相分离和增强子-启动子相互作用，从而促进巨噬细胞中IL- 6的转录、从而重塑肿瘤微环境。

2023年4月1日 · Tumor-associated macrophages are mainly polarized into the M2 phenotype, which remodels the tumor microenvironment and promotes tumor progression by secreting various cytokines. Herein, we reported that Yin Yang 1 (YY1) was highly expressed on tumor-infiltrated M2 macrophages in prostate cancer and was associated with poorer clinical outcomes.