2024年12月25日 · ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include Mowat-Wilson Syndrome and Large Congenital Melanocytic Nevus. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

2024年1月25日 · Dai et al. report that the transcription factor ZEB2 is critical in driving ABC formation and pathogenicity in both mice and humans. ZEB2 promotes the gene signature, phenotype (e.g., CD11c expression), and function (e.g., phagocytic ability) of ABCs.

Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability to bind Smad proteins, and consists of multiple functional domains which interact with a variety of transcriptional co-effectors.

ZEB2, originally named SIP1 (and ZFHX1B), was discovered in a yeast 2-hybrid screening together with other candidate SMAD-interacting proteins (SIPs) from mid-gestation mouse embryos, using the transcription activation (i.e., MH2) domain of BMP-SMAD1 as bait [1].

2024年1月26日 · In mice with toll-like receptor 7 (TLR7)-driven lupus, ZEB2 is essential for ABC formation and autoimmune pathology. ZEB2 binds to +20-kb myocyte enhancer factor 2b (Mef2b)'s intronic enhancer, repressing MEF2B-mediated germinal center B cell differentiation and promoting ABC formation.

The ZEB2 gene provides instructions for making a protein that plays a critical role in the formation of many organs and tissues before birth. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.

2019年2月1日 · The two high ZEB2-expressing clones demonstrated robust increases in invasive capacity, as assessed by three types of invasion assay. These data identify ZEB2-mediated transcription as a key mechanism transforming the epithelial-like trophoblast into cells with a mesenchymal, invasive phenotype.

2015年9月1日 · Zeb2 regulates CNS and PNS induction and development. The effect of the knockdown of Zeb2 on nervous system development described. Molecular and cellular mechanisms of Zeb2-regulation of neurogenic and gliogenic …

ZEB2 refers to a multifunctional regulator that plays an essential role in the development of the nervous system. It controls the formation of various neural populations and is involved in processes such as gliogenesis and myelinogenesis.

Studied zinc finger E-box binding homeobox 2 (ZEB2) as a tumor marker for staging/outcome of colorectal cancer; findings suggest that expression of ZEB2 is associated with poor oncologic outcome and distant recurrence.