A universal deep-learning model for zinc finger design enables ...
2023年1月26日 · Here we describe the screening of 49 billion protein–DNA interactions and the development of a deep-learning model, ZFDesign, that solves ZF design for any genomic target.
带有重金属离子的DNA锚定蛋白——锌指蛋白 (ZF) - 哔哩哔哩
锌指结构域 (Zinc Finger, ZnF)是一种相对较小的蛋白质基序，它包含多个指状突起，可与靶分子串联接触。 其中一些区域与锌结合，但也有许多不结合，而是与铁等其他金属结合，或者根本 …
Updated understanding of the protein–DNA recognition
2024年8月1日 · Among these, three structural classes of DNA-binding proteins account for most TFs: Cys2-His2 (C2H2) zinc-finger (ZF) proteins (∼700), homeodomain proteins (∼250), and …
New Insights into DNA Recognition by Zinc Fingers Revealed by ...
2013年4月12日 · Classical zinc fingers (ZFs) are one of the most abundant and best characterized DNA-binding domains. Typically, tandem arrays of three or more ZFs bind DNA …
Engineering and Application of Zinc Finger Proteins and TALEs for ...
Zinc fingers (ZF) are one of the most common DNA-binding domains and have been extensively studied for a variety of applications, such as gene regulation, genome engineering and …
Certificates - ZF
On this page you will find the current certificates of the ZF sites, world wide. You might either use the following selection possibilities in order to find the desired Certificate or directly enter a …
锌指核糖核酸酶 - 百度百科
锌指 核酸酶 （ZFNs）由一个DNA识别域以及一个DNA剪切域组成。 DNA识别域为3～4个ZF串联结构，每个ZF约含30个 氨基酸，被1个 锌离子 所固定，可识别并结合1个特异的三联体 碱 …
Activation of recombinases at specific DNA loci by zinc-finger
2024年1月31日 · In this study, we fused zinc-finger DNA-binding domains (ZFDs) to Cre-type recombinases. We performed systematic analyses to define the optimal spacing and …
Artificial Zinc Finger DNA Binding Domains: Versatile Tools for …
This review focuses on the structure, design, and applications of ZF DNA binding domains (ZFDBDs). ZFDBDs are relatively small and have been shown to penetrate the cell membrane …
DeepZF: improved DNA-binding prediction of C2H2-zinc-finger
2022年9月16日 · Results: We present DeepZF, a deep-learning-based pipeline for predicting binding ZFs and their DNA-binding preferences given only the amino acid sequence of a C2H2 …