2024年12月25日 · This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type ...

Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome. [5] This gene on the X chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of …

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type ...

2020年5月14日 · ZFX and ZFY are nearly identical proteins encoded on either the X or Y chromosome, respectively (having 96% overall similarity, with 99% similarity in the zinc finger domains). ZNF711 is highly related to the other two family members, having 67% overall similarity with ZFX and 87% similarity in the zinc finger domains (Figure 1 ).

2023年12月29日 · 12月13日发表在《细胞 基因组学》（Cell Genomics）杂志上的这项研究表明，X和Y染色体上表达的基因会影响全身的细胞，而不仅仅是生殖系统中的细胞，它们会调高或调低其他染色体上数千个基因的表达。 全套 人类染色体 的核型。 资料来源：美国国家人类基因组研究所. ZFX和ZFY：关键基因调控因子. 此外，研究人员还发现，负责大约一半调. 一项突破性研究揭示，性染色体，尤其是通过基因 ZFX 和 ZFY在调节整个人体的基因表达方面发挥着关键作用， …

The human zinc finger protein genes (ZFX/Y) were identified as a result of a systematic search for the testis-determining factor gene on the human Y chromosome. Although they play no direct role in sex determination, they are of particular interest …

2024年12月25日 · ZFY (Zinc Finger Protein Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include Freemartinism and Campomelic Dysplasia . An important paralog of this gene is ZFX .

2024年3月28日 · Page et al. (1987) identified a Y-encoded zinc finger protein (ZFY; 490000). A similar DNA sequence, ZFX, was identified on the X chromosome. Using PCR, Palmer et al. (1990) demonstrated close similarity of ZFY and ZFX. Both genes were expressed in a wide range of adult and fetal human tissues, and ZFX was expressed from the inactive X ...

Putative transcription activator with alternative isoforms encoded by human ZFX gene. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. Comparison of human ZFY and ZFX transcripts.

ZFX是krueppel C2H2-型锌指蛋白家族成员，最近，不少研究指出，ZFX在恶性肿瘤的发生、发展过程中也发挥重要功能。 本项课题通过免疫组化及临床病理资料分析，发现ZFX在胆囊癌组织中高表达，且其表达量与患者的组织学分化程度、周围神经浸润及切缘情况有关。