Zip Nucleic Acids (ZNA®) are a novel class of modified oligonucleotides enhancing hybridization properties of nucleic acids. ZNA® are oligonucleotides conjugated to cationic units. ZNA® show increased affinity for their targets by reducing the electrostatic repulsion …

From antisense technology to in-situ hybridization, ZNA® oligos have proven their efficacy in a range of applications. Zip nucleic acids (ZNA®s) are oligonucleotides conjugated with cationic spermine units (1).

Z-Hunt算法根据B-DNA和Z-DNA之间的自由能差预测Z-DNA的稳定性，可对负超螺旋诱导的B-DNA到Z-DNA的转变进行序列分析 [197]。 通过计算发现，1 Mb的人类DNA片段 (包含137个基因)中有329个潜在的Z-DNA形成位点，其中许多序列位于转录起始位点附近 [197]。

2024年4月30日 · An acyclic phosphonate-linked nucleic acid backbone (ZNA) demonstrated the capability to support duplex formation and propagate genetic information in vivo, unveiling its potential for evolution into a synthetic genetic system (XNA).

ZNA® (Figure 1) stands for Zip Nucleic Acid, which consist in oligonucleotides conjugated with cationic spermine units. This asset decreases the electrostatic repulsion between single strand nucleic acids (i.e. between primer/probe and target DNA during annealing).

ZNAs are oligonucleotide-oligocation conjugates whose global charge is modulated by the number of cationic spermine moieties grafted on the oligonucleotide. It was demonstrated that the melting temperature of a hybridized ZNA is easily predictable and increases linearly with the length of the oligocation.

目的探讨ZNA (ZIP Nucleic Acid)探针的PCR性能及其在沙眼衣原体 (CT)核酸定量检测中的研究.方法使用CT阳性质粒,比较偶联不同ZIP数量的ZNA探针的PCR扩增曲线差异;比较ZNA探针与29mer普通Taqman探针 (DNA长探针),20mer普通Taqman探针 (DNA短探针),MGB探针在PCR扩增曲线,反 …

Zip nucleic acids (ZNA®s) are oligonucleotides conjugated with cationic spermine units. This asset decreases the electrostatic repulsion between single-stranded nucleic acids (i.e. between primer/probe and target DNA during annealing), therefore increasing the affinity of ZNA® primers and probes to their targets.

2016年5月13日 · ZNA ® are a novel class of modified oligonucleotides enhancing hybridization properties of nucleic acids. ZNA ® are oligonucleotides conjugated to cationic units. Their global charge can be modulated by the number of cationic spermine moieties grafted on …

ZNA® are a novel class of modified oligonucleotides enhancing hybridization properties of nucleic acids. ZNA are oligonucleotides conjugated to cationic units. Their global charge can be modulated by the number of cationic spermine moieties grafted on each oligonucleotide.