Zinc finger (Znf) domains are relatively small protein motifs that contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not, instead binding other metals such as iron, or no metal at all.

Nov 13, 2017 · Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological...

Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression ...

Mammalian genomes carry hundreds of Krüppel -type zinc finger (ZNF) genes, most of which reside in familial clusters. ZNF genes encoding Krüppel -associated box (KRAB) motifs are especially prone to this type of tandem organization.

Jan 9, 2022 · As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of biological functions.

Jul 25, 2024 · Zinc finger proteins (ZNF), a unique yet diverse group of proteins, play pivotal roles in fundamental cellular mechanisms including transcription regulation, chromatin remodeling, protein/RNA homeostasis, and DNA repair.

Zinc finger (ZnF) proteins are a massive, diverse family of proteins that serve a wide variety of biological functions.

A complete list of ZNF types with a description of the zinc-finger domain structure, the number of genes included, and the most studied members is summarized in Table 1. The most important and abundant types of zinc-finger domain proteins include C2H2, really interesting new gene (RING), plant homeodomain (PHD), and Lin-ll, Isl-1, and Mec-3 ...

Nov 12, 2021 · Other DNA-binding proteins such as Zinc Finger (ZnF) domain-containing proteins have also been implicated in DNA repair, but their role in cNHEJ remained elusive. Here we show that ZNF384, a...

Nov 18, 2021 · Zinc finger proteins (ZNF) can form transcription initiation complexes that bind to DNA-specific regions and mediate transcription. ZNF mainly rely on Zn 2+ to form a stable structure similar to “finger” (Berg and Shi, 1996). Zn 2+ binds with different amounts of Cys and His to form different types of ZNF. ZNF are classified in two ...