The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior axis. Limb bud is …

A-P patterning is established by the Zone of Polarizing Activity (ZPA) on the posterior side of the limb (i.e. the little finger side). Shh signaling from the ZPA specifically signals the formation of …

Two key signalling centres drive vertebrate limb development: the apical ectodermal ridge (AER) and the zone of polarising activity (ZPA). Embryological manipulations of the chick limb bud …

The zone of polarizing activity (ZPA) corresponds to a group of cells located in the posterior mesenchyme of the limb bud that act as an organizer of the AP polarity of the limb (Figure 10 …

Among John Saunders’ many seminal contributions to developmental biology, his discovery of the limb ‘zone of polarizing activity’ (ZPA) is arguably one of the most memorable and ground …

1993年12月31日 · We have isolated a vertebrate gene, Sonic hedgehog, related to the Drosophila segment polarity gene hedgehog, which is expressed specifically in the ZPA and in other …

1993年12月31日 · The zone of polarizing activity (ZPA) is a region at the posterior margin of the limb bud that induces mirror-image duplications when grafted to the anterior of a second limb. …

The second signaling center is the zone of polarizing activity (ZPA), which is a group of limb mesenchymal cells formed at the posterior margin of the limb bud. The polarizing activities of …

2009年1月13日 · Another signaling center is the zone of polarizing activity (ZPA), which refers to a group of mesenchymal cells at the posterior limb margin that controls digit identities along …

2022年8月16日 · Shh is secreted by posterior limb bud mesoderm cells, defined functionally as the “zone of polarizing activity” (ZPA). Shh/ZPA regulates the specification of distinct A-P digits …