
ZSCAN4 Gene - GeneCards | ZSCA4 Protein | ZSCA4 Antibody
2024年12月25日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
ZSCAN4 facilitates chromatin remodeling and promotes the
2020年6月7日 · In this study, we investigate the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in human head and neck squamous cell carcinoma (HNSCC). The murine Zscan4 is involved in telomere...
Zscan4 binds nucleosomal microsatellite DNA and protects
2020年3月20日 · Zscan4-associated microsatellite regions are characterized by low nuclease sensitivity and high histone occupancy. In vitro, Zscan4 binds nucleosomes and protects them from disassembly upon torsional strain. Furthermore, Zscan4 depletion leads to elevated DNA damage in 2C mouse embryos in a transcription-dependent manner.
ZSCAN4在早期胚胎及多能干细胞中的作用及调节机制
ZSCAN4能够调控早期胚胎发育过程,在合子基因组激活(zygotic genome activation, ZGA)期间通过促进DNA损伤修复和纠正染色体异常,以维持植入前胚胎的基因组和染色体完整性。
Zscan4 mediates ubiquitination and degradation of the …
2024年12月20日 · Zscan4 exhibits burst expression in 2C embryos and 2C-like cells. Here, we show that Zscan4 mediates chromatin remodeling to promote the chromatin accessibility for achieving the 2C-like state. Through coimmunoprecipitation/mass spectrometry, we identified that Zscan4 interacts with the corepressors Kap1/Trim28, Lsd1, and Hdac1, also with ...
Zscan4 regulates telomere elongation and genomic stability in
2010年3月24日 · We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term genomic stability in ES cells....
A Comprehensive Review on the Role of ZSCAN4 in Embryonic …
ZSCAN4 is a transcription factor that plays a pivotal role during early embryonic development. It is a unique gene expressed specifically during the first tide of de novo transcription during the zygotic genome activation. Moreover, it is reported to regulate telomere length in embryonic stem cells and induced pluripotent stem cells.
Zscan4 binds nucleosomal microsatellite DNA and protects …
2020年3月20日 · Zinc finger protein Zscan4 is selectively expressed in mouse two-cell (2C) embryos undergoing zygotic genome activation (ZGA) and in a rare subpopulation of embryonic stem cells with 2C-like features. Here, we show that Zscan4 specifically recognizes a subset of (CA) n microsatellites, rep …
Zscan4: a novel gene expressed exclusively in late 2-cell ... - PubMed
2007年7月15日 · Utilizing DNA microarray data, we looked for genes that are expressed only during ZGA and found Zscan4, whose expression is restricted to late 2-cell stage embryos. Sequence analysis of genomic DNA and cDNA clones revealed nine paralogous genes tightly clustered in 0.85 Mb on mouse chromosome 7.
ZSCAN4 zinc finger and SCAN domain containing 4 [ (human)]
2025年2月8日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]