Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. [5] [6] [7] ATGL catalyses the first reaction of lipolysis, [8] where triacylglycerols are hydrolysed to …

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis and produces FAs used for energy production. There is growing evidence that the products and ...

2022年6月8日 · Here we identified adipose triglyceride lipase (ATGL, also known as patatin-like phospholipase domain containing 2 (PNPLA2)) as a candidate biosynthetic enzyme for FAHFAs...

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the …

ATGL initiates the hydrolysis of TGs to release fatty acids (FAs) that are crucial energy substrates, precursors for the synthesis of membrane lipids, and ligands of nuclear receptors. Thus, ATGL is a key enzyme in whole-body energy homeostasis.

Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis. ATGL specifically hydrolyzes triacylglycerols (TGs), thereby generating diacylglycerols and free fatty acids. ATGL's enzymatic activity is co-activated by the protein comparative gene identification-58 (CGI-58) and inhibited by the protein G0/G1 switch gene 2 (G0S2).

2019年11月22日 · The discovery of adipose triglyceride lipase (ATGL) as a triglyceride lipase provided a heightened understanding of the mechanisms governing mobilization of fat reserves from adipose tissue. ATGL catalyses the initial step in adipose triglyceride lipolysis, working in concert with other enzymes to mobilize triglyceride for energy production.

The enzyme adipose triglyceride lipase (ATGL) catalyzes the initial and often rate-limiting step of intracellular lipolysis [11]. This involves the conversion of a triacylglycerol molecule to diacylglycerol, which releases a fatty acid [11].

3 天之前 · Adipose triglyceride lipase (ATGL), the rate-limiting enzyme for TG hydrolysis, is another critical regulator of lipid turnover [12]. Loss of ATGL function leads to steatosis, while its overexpression alleviates this condition and directs liberated fatty acids toward oxidative pathways 13, 14. Despite the well-documented roles of FXR and ATGL ...

2025年3月10日 · ATGL serves as a pivotal enzyme in the balance of lipid synthesis and degradation, influencing cellular energy stores and systemic metabolic health. By liberating fatty acids, ATGL facilitates their availability for β-oxidation, crucial for ATP production in tissues with high energy demands.