c-FLIP, a master anti-apoptotic regulator - PubMed
Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas …
Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy
Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a major antiapoptotic protein and an important cytokine and chemotherapy resistance factor that …
c-FLIP在凋亡增殖中的双向调节作用及与肿瘤预后和治疗关系的研究
摘要: 细胞型Fas相关死亡域样白介素-1β转换酶抑制蛋白(c-FLIP) 在细胞凋亡和增殖信号通路中具有重要的调节作用。一方面通过与Caspase-8竞争性结合上游信号阻断凋亡通路, 另一方面经 …
c-FLIP regulates autophagy by interacting with Beclin-1 and
2021年7月8日 · In line with the role of c-FLIP as a scaffold protein, we found that c-FLIPL interacts with Beclin-1 (BECN1: coiled-coil, moesin-like BCL2-interacting protein), which is …
凋亡抑制蛋白c-FLIP参与肿瘤发生的机制研究 - 百度百科
肿瘤的发生与细胞凋亡的失衡有密切关系，c-FLIP是重要的一种抗凋亡蛋白，能够使肿瘤细胞抵抗Fas或TRAIL等死亡受体（DR）诱导的凋亡，逃逸机体的免疫监视，已成为抗肿瘤治疗靶点之 …
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for ...
Cellular FLICE-like inhibitory protein (c-FLIP) has been identified as a protease-dead, procaspase-8-like regulator of death ligand-induced apoptosis, based on observations that c …
肿瘤抗凋亡调节因子c-FLIP专一抑制剂的研究 - 百度百科
c-FLIP 家族蛋白是死亡受体信号中重要的调节因子，通过与procaspase-8 竞争结合到接头蛋白FADD上，抑制凋亡发生。 在某些肿瘤细胞系中，c-FLIP 的过表达是肿瘤细胞对死亡受体介 …
c—FLIP在凋亡增殖中的双向调节作用及与肿瘤预后和治疗关系的研 …
C-FLIP（cellular FADD-like interleukin-1beta-converting enzyme-inhibitory protein）是一种肿瘤坏死因子(TNF)信号途径上的负调节蛋白，能够抑制TNF诱导的细胞凋亡。 PEDF和C-FLIP在多 …
A role for c-FLIP L in the regulation of apoptosis, autophagy, …
2012年11月23日 · Cellular caspase 8 (FLICE)-like inhibitory protein (c-FLIP) is a potential regulator for apoptosis, autophagy, and necroptosis in primary T lymphocytes.
Pharmacological targeting of c-FLIP - Nature
2020年11月30日 · The short c-FLIP isoforms, c-FLIP S and c-FLIP R, block DR-induced apoptosis by inhibiting procaspase-8 activation at the DED filament and at the DISC 19,20. c …