2022年12月10日 · ScRNAseq of the neutropenic bone marrow predicted cellular crosstalk between mature neutrophils expressing CCL6, a known chemoattractant for interferon-producing NK cells, and activated Ccr2 ...

2021年8月31日，四川大学华西医院生物治疗国家重点实验室魏霞蔚团队在 Cell Proliferation 上发表了题为“Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting”的综述性论文。 在本文中，团队总结了CCL2-CCR2信号轴在肿瘤发生发展中的作用，并重点介绍了其靶向治疗肿瘤的最新研究，尤其针对临床前研究和临床试验。 趋化因子是小分子蛋白，其通过与细胞表面 G蛋白偶联趋化因子受体 （GPCR）结合来发挥其功能。

2019年11月19日 · We determined CCL6 expression in neurons and astrocytes using RT-PCR. In these experiments, CCL6 was not expressed in primary cultures of cerebral cortex neurons or astrocytes. However, CCL6 expression was confirmed in FACS-sorted astrocytes that had been grown in neuron–astrocyte mixed cultures (Fig. 2 C). Thus, we determined CCL6 ...

收集野生型c57bl/6和纯合b-hccr2小鼠的骨髓，并用种属特异性抗ccr2抗体进行流式细胞术分析。 结果显示：鼠CCR2仅在野生小鼠中检测到，人CCR2仅在纯合B-hCCR2小鼠中检测到。

2024年10月1日 · Within the tumor colonies, CCR2+ nonclassical monocytes secreted CCL6 to recruit NK cells that mediated tumor regression, independent of T and B lymphocytes. Hence, pharmacological induction of CCR2+ nonclassical monocytes might be useful for immunotherapy-resistant cancers.

2024年11月15日 · Within the tumor colonies, CCR2 + nonclassical monocytes secreted CCL6 to recruit NK cells that mediated tumor regression, independent of T and B lymphocytes. Hence, pharmacological induction of CCR2 + nonclassical monocytes might be useful for immunotherapy-resistant cancers.

2024年7月26日 · In this study, we used single-cell RNA-sequencing analysis of Cd45 + CD11b + F4/80 + cardiac macrophages to explore the heterogeneity of cardiac macrophages. The CCR2 + (C-C chemokine receptor 2) macrophages were specifically removed by a dual recombinase approach, and the macrophage CCR2 was deleted to investigate their functions.

Our findings reveal that mechanical force-induced functional shift of the Ccr2 macrophages cluster mediated by NF-κB pathway, leading to a pro-inflammatory response and bone remodeling. This macrophage cluster may represent a potential target for the manipulation of OTM.

2021年9月21日 · We find alterations in transcriptional profiles of microglia subsets in Ccr2−/− TBI mice compared to WT TBI mice indicating that infiltrating monocytes/macrophages influence microglia activation to promote a type I IFN response.

Using primary cortical microglial cell cultures, we observed a substantial increase in the expression of CCL2, CCL7, and CCL12 after 24 h of LPS (100 ng/mL) treatment. CCL2 stimulation of microglia increased the level of IL-1β mRNA but did not influence the expression of IL-18, IL-6, and IL-10.