2015年7月16日 · Here we show that wild-type D2HGDH elevates α-KG levels, influencing histone and DNA methylation, and HIF1α hydroxylation. Conversely, the D2HGDH mutants that we …

2024年12月30日 · Numerous clinical reports have shown that downregulation of D2HGDH causes elevated D-2-HG levels, and D2HGDH mutations are associated with neonatal epileptic …

hot和d2hgdh可能导致lps刺激的巨噬细胞中d-2hg升高. 2hg 水平可以通过特异性合成和降解两种对映异构体的各种酶进行调节，如图 2a 中 d-2hg 的示意图中详述。

Three different mechanisms were proposed for the hypoxia-induced L-2-HG elevation: reduced malate and increased NADH favoring the promiscuous reaction of MDH2, reduced D2HGDH …

2021年1月12日 · D-2-HGDH is the only known enzyme responsible for the conversion of D-2-HG into 2-OG to keep D-2-HG at a normal physiological level in the cells 17.

2023年2月28日 · In this study, we investigated the role of D2HGDH in adult hippocampal neurogenesis. Specific ablation of D2HGDH from Nestin-expressing cells led to impaired RGL …

In humans, mutations in D-2-hydroxyglutarate dehydrogenase (D2HGDH) cause delayed development, seizures and ataxia. This study shows that in the nematode Caenorhabditis …

2022年3月2日 · In vivo xenograft experiments confirmed that D2HGDH-OE CAR-T cells decreased serum D2HG and improved the overall survival of mice bearing NALM6 cancer …

In this study, downregulation of D2HGDH affects modulation of ROS levels, synaptic transmission, and seizure susceptibility. Furthermore, the acid calcium-independent …

Here we show that wild-type D2HGDH elevates a-KG levels, influencing histone and DNA methylation, and HIF1a hydroxylation. Conversely, the D2HGDH mutants that we find in …