DC-SIGN - Wikipedia
DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found
DC-SIGN Family of Receptors - PMC - PubMed Central (PMC)
DC-SIGN is a prototype C-type lectin organized in microdomains, which have their role as pathogen recognition receptors in sensing microbes. Although the integrin LFA-1 is a counter-receptor for both ICAM-2 and ICAM-3 on DC, DC-SIGN is …
DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC …
DC-SIGN, which is expressed by dendritic cells, binds to ICAM-3 on T-lymphocytes, therefore playing an important role in the activation of T-lymphocytes. DC-SIGN can also bind HIV, and the virus may remain bound to DC-SIGN for protracted periods.
人DC-SIGN蛋白克隆及免疫学功能初探 - 百度学术
DC-SIGN全称是树突状细胞特异性细胞间粘附分子-3-结合非整合素分子(dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintergrin,DC-SIGN),又称CD209,表达在未成熟的树突状细胞(immature dendritic cells,iDCs)表面,主要作用是捕获抗原和参与细胞间粘附.多种病原体通 …
C-type lectin DC-SIGN: An adhesion, signalling and antigen …
Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II transmembrane lectin receptor. Attention on DC-SIGN has increased greatly in recent years due to important discoveries documenting its immune-related functions and cell-specific expression that is mostly restricted to DCs.
DC-SIGN通路在免疫调节中的作用 - 豆丁网
2011年4月16日 · 【摘要】DC-SIGN是在DC表面发现的II型跨膜凝集素受体，能够与细胞间黏附因子2（ICAM-2）和ICAM-3结合，并能识别结合含高甘露糖（3个甘露糖）的碳水化合物和含岩藻糖的多糖结构（如Lex,Ley,Lea及Leb）等病原相关分子模式【1】，一方面可以通过受体介导的内吞、摄取、处理、提呈可溶性抗原，诱发对病原体的免疫应答【2】；另一方面DC-SIGN通路能下调宿主免疫应答，导致病原扩散、传播、免疫抑制和持续性感染【3-6】。 近些年来，人们通过 …
DC-SIGN: escape mechanism for pathogens - Nature
2003年9月1日 · Cell- and tissue-specific glycosylation of a glycoprotein regulates the expression of carbohydrate residues and recognition by specific C-type lectins. The C-type lectin DC-SIGN recognizes a wide...
DC—SIGN与肿瘤关系的研究进展 - 百度文库
DC-SIGN不仅能与细胞间黏附分子-2（intercellular adhesion molecule-2，1-CAM-2）和细胞间黏附分子-3（intercellular adhesion molecule-3，ICAM-3）等结合，还能识别HIV、登革病毒、巨细胞病毒等病原微生物，从而参与了这些病原体的感染过程，与多种感染性疾病的发病机制密切相关。
DC-SIGN和免疫调节。,Cellular & Molecular Immunology - X-MOL
dc-sign是一种称为cd209的分子，是c型凝集素超家族的一个成员。它不仅是模式识别受体，而且还与dc的免疫调节有关。dc-sign由于其在介导dc粘附，迁移，炎症，激活原代t细胞，触发免疫反应以及参与病原体和肿瘤的免疫逃逸中的重要作用而成为近期研究的热点。
DC-SIGN受体及其信号通路在病原体感染中的作用 - 百度学术
树突细胞特异性细胞间黏附分子-3-结合非整合素分子 (DC - SIGN)首先是在DC表面发现的Ⅱ型跨膜凝集素受体,能够与细胞间黏附因子2 (ICAM-2)和ICAM -3结合,并能识别结合富含甘露糖的碳水化合物和含岩藻糖的多糖结构 (如Lex,Ley,Lea及Leb)等病原相关分子模式,一方面可以通过受体介导的内吞,摄取,处理,提呈可溶性抗原,诱发机体对病原体的免疫应答;另一方面DC - SIGN诱发的信号通路能下调宿主免疫应答,导致病原体扩散,传播,免疫抑制和持续性感染.近年来,人们通过对许多病原 …