TANK 可将上游 RLR 信号转导连接至 TANK 结合激酶 1 (TBK1)，TBK1 会诱导干扰素调节因子 3 (IRF-3) 的磷酸化。 IRF-3 磷酸化和随后的二聚化会诱导 IRF-3 核转位，IRF-3 随后结合干扰素刺激应答元件 (ISRE)，从而导致 I 型干扰素基因表达。 胞质双链 DNA 检测也通过多个入口流入 TBK1-IRF-3 信号转导轴。 主要的胞质 DNA 结合感应蛋白是环 GMP-AMP 合成酶 (cGAS)，cGAS 通过产生环二核苷酸 c-GMP-AMP (cGAMP) 对 DNA 结合产生反应。 cGAMP 结合 STING 并激活 …

2020年12月3日 · TBK1-mediated phosphorylation of DRP1 was efficient and exhibited a dominant-negative effect, completely eliminating the mitochondrial incision function of DRP1. This TBK1-DRP1 axis was critical for innate RNA sensing and antiviral immunity, and it linked cellular nutrient sensing to mitochondrial dynamics.

2003年4月14日 · We have shown that TLR3 and TRIF function upstream in the signaling pathway leading to the activation of IKKε and TBK1 by dsRNA. IKKε and TBK1 can promote the interaction between...

tbk1在有丝分裂调控中的重要作用为靶向tbk1治疗癌症，尤其是kras突变依赖性疾病的潜力提供了进一步的证据。 Zhu等人提供了RalB-TBK1如何驱动KRAS诱导的肺癌的见解。

2024年10月1日 · According to a recent preprint manuscript, double-stranded DNA (dsDNA) and dsRNA can induce TBK1 activation through multiple distinct pathways, in addition to the well-established cGAS/STING or RIG-I/MAVS signaling complex (Ye et al., 2022). For example, even with cGAS or STING depletion, dsDNA treatment still can induce TBK1 Ser172 ...

We demonstrated that TLR3 stimulation by dsRNA induces the phosphorylation of TRIF at Ser210, which is within the pLXIS-like motif, and is essential for the interaction between TRIF and IRF-3. TBK1 may be responsible for phosphorylation of Ser210.

2021年8月15日 · Nuclear-derived dsRNA is packaged into extracellular vesicles and subsequently recognized by toll-like receptor 3 (TLR3) to activate TBK1 and downstream MHC class I expression in an autocrine or paracrine manner before being degraded in lysosomes. MYC suppressed loading of dsRNA onto TLR3 and its subsequent …

2024年6月1日 · Recent work has confirmed that TBK1 is a cancer immune evasion gene and demonstrated that targeting TBK1 enhances the response to ICB, both by sensitizing cancer cells to inflammatory cell death following immune challenge and by augmenting the antitumor function of tumor-infiltrating lymphoid and myeloid cells [20] (Figure 1 A, Key figure ...

2017年11月21日 · 国际著名免疫学术期刊PLOS Pathogens和The Journal of Immunology分别在线发表了北京大学生命科学学院蒋争凡研究组在抗病毒天然免疫领域的最新研究成果——“MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner”及“NEMO–IKKβ Are Essential for IRF3 and NF-κB ...

2020年11月21日 · TANK-binding kinase 1 (TBK1) is a Ser/Thr kinase with a central role in coordinating the cellular response to invading pathogens and regulating key inflammatory signaling cascades. While intact TBK1 signaling is required for successful anti-viral ...