EEF2K - Wikipedia
eEF-2 kinase is a highly conserved protein kinase in the calmodulin -mediated signaling pathway that links multiple up-stream signals to the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. [6][8] The activity of eEF-2K is dependent on calcium and calmodulin.
Nature子刊：治疗癌症激酶新靶标eEF2K：尚无选择性抑制剂
2021年7月20日 · 真核细胞延伸因子2激酶（eEF2K）是α-激酶家族的一个非典型成员，与经典蛋白激酶没有序列相似性。eEF2K在肿瘤发生、发展过程中发挥关键调节作用，在不同癌症中上调并与患者预后不良相关，使得人们对其作为抗癌靶点的潜力越来越感兴趣.
EEF2K Gene - GeneCards | EF2K Protein | EF2K Antibody
2024年12月24日 · EEF2K (Eukaryotic Elongation Factor 2 Kinase) is a Protein Coding gene. Diseases associated with EEF2K include Tuberous Sclerosis and Lung Cancer. Among its related pathways are MTOR signalling and Translation Insulin regulation of translation.
真核细胞延伸因子 2 激酶（EEF2K）基因 | MCE
Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues. 该基因在钙调蛋白介导的信号通路中编码一种高度保守的蛋白激酶，该通路将细胞表面受体的激活与细胞分裂联系起来。 该激酶参与蛋白质合成的调节。 它使真核生物延伸因子 2 (EEF2) 磷酸化，从而抑制 EEF2 功能。 这种激酶的活性在许多癌症中增加，可能是抗癌治疗的有效靶标。 [RefSeq 提供，2008 年 7 月]
【李静课题组】真核延伸因子2激酶参与调控肺癌细胞增殖作用及 …
2020年5月3日 · 真核延伸因子2激酶（eEF2K）是一种Ca2+/CaM依赖性蛋白激酶，不同于常见的蛋白激酶，属于少数的“α-激酶”家族，因此靶向eEF2K可以避免因对大多数激酶影响而产生的毒副作用。
eEF2K: an atypical kinase target for cancer - Nature
2021年7月13日 · eEF2K was reported in the late 1980s as a structurally and functionally unique protein kinase involved in calmodulin-mediated signalling pathways. Its substrate, eEF2, helps ribosomes proceed...
eEF2K as an important kinase associated with cancer survival and ...
2024年11月26日 · Eukaryotic Elongation Factor 2 Kinase (eEF2K), a member of the α-kinase family, services as a crucial negative regulator of protein synthesis, particularly...
The eEF2 kinase coordinates the DNA damage response to
2024年7月13日 · Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA...
真核延伸因子2激酶与肿瘤 - 仁和软件
2015年7月3日 · Abstract: Eukaryotic elongation factor 2 kinase (eEF2K) is well known as a Ca 2+ /calmodulin (CaM)-dependent kinase. eEF2K catalyzes the phosphorylation of eEF2 and subsequently inactivates eEF2 by impairing its ability to bind to the ribosome, thereby negatively modulates protein synthesis.
EEF2K eukaryotic elongation factor 2 kinase [ (human)]
2025年2月8日 · Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.