TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, …
2009年6月15日 · Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer.
A genome-wide CRISPR screening uncovers that TOB1 acts as a …
To further explore the effect of TOB1 on EGFR/ERBB2-mediated FMDV entry, we investigated the EGFR pathway in IBRS-2 and PK-15 cells. We stimulated the cells with epidermal growth factor (EGF), which can activate the EGFR pathway and transmit phosphorylation signals downstream to phosphorylate AKT.
TOB1 is regulated by EGF-dependent HER2 and EGFR signaling, is …
2009年6月15日 · Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer. In a cellular model of this phenotype using differential gene expression analysis, we identified …
A genome-wide CRISPR screening uncovers that TOB1 acts as a
2024年3月21日 · Follow-up studies confirmed the dependency of FMDV on these genes, and we identified a functional role for one of the FMDV-related host genes: TOB1 (Transducer of ERBB2.1). TOB1-knockout significantly inhibits FMDV infection by positively regulating the expression of RIG-I and MDA5.
Transducer of erbB2.1 is a potential cellular target of gefitinib in ...
2012年10月15日 · These results suggest that TOB1 interacting with cyclin D1 and nuclear translocation have a direct role in mediating the gefitinib-induced proliferative arrest. Taken together, our data showed that TOB1 may be a potential target …
High expression of Tob1 indicates poor survival outcome and …
2018年11月17日 · TOB1 is regulated by EGF-dependent HER2 and EGFR signaling, is highly phosphorylated, and indicates poor prognosis in node-negative breast cancer. Cancer Res. 2009; 69 :5049–5056. doi: 10.1158/0008-5472.CAN-08-4154.
(PDF) TOB1's Role in HER2/EGFR Cancer Signaling and Prognosis
Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer.
全基因组 CRISPR 筛选发现 TOB1 通过 IFN 和 EGFR 介导途径充当 …
tob1 -敲除通过正向调节rig-i和mda5的表达来显着抑制fmdv感染。我们进一步发现tob1 -敲除导致转录因子cebpa的mrna转录本及其蛋白质的积累更多，这进一步增强了转录因子cebpa的转录rig-i和丙二醛5基因。此外， tob1 -敲除可抑制 egfr/erbb2 途径介导的 fmdv 吸附和内化。
TOB1 Is Regulated by EGF-Dependent HER2 and EGFR
2009年7月1日 · Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast...
TOB1 phosphorylation might abrogate the antiproliferative effect of TOB1 in breast cancer. This suggests a new regulatory role for TOB1 in cancer progression with particular signifi-
- 某些结果已被删除