真核起始因子4E - 维基百科，自由的百科全书
真核起始因子4E （英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种 帽结合蛋白，可以特异性地识别 mRNA 的 5'端 的 帽子结构，它在 真核翻译 的起始过程中发挥重要作用。 …
EIF4E - Wikipedia
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. [5][6] Most eukaryotic cellular mRNAs are blocked at their 5' …
eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA …
1997年8月29日 · We have demonstrated that eIF4G significantly enhances the cap recognition activity of eIF4E, suggesting that eIF4G plays an important role in the mechanism of mRNA …
eIF4E 活性的控制：结构见解和药理学意义,Cellular and Molecular …
eIF4E 和真核起始因子 4G (eIF4G) 之间的相互作用对于翻译机器的组装至关重要，这是 mRNA 翻译的初始步骤。 一组特征明确的蛋白质，称为 4E 结合蛋白 (4E-BPs)，通过竞争 eIF4E 表面 …
The Structures of eIF4E-eIF4G Complexes Reveal an Extended
2016年11月3日 · Our studies provide a molecular model of the eIF4E-eIF4G complex, shed light on the competition mechanism of 4E-BPs, and enable the rational design of selective eIF4G …
eIF4G as a switch for heat shock mRNA translation - Cell Press
2024年5月2日 · In this issue of Molecular Cell, 1 Desroches Altamirano et al. reported a scaffold protein in protein translation initiation, called eIF4G, as a thermosensor during the heat shock …
The mRNA cap-binding protein eIF4E in post-transcriptional …
2004年5月25日 · Binding of eIF4E and eIF4G to the cap via the activity of eIF4E is essential for translation both in vivo and in vitro. On the other hand, contacts between eIF4G and the poly …
The Structures of eIF4E-eIF4G Complexes Reveal an Extended ... - PubMed
2016年11月3日 · Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This interaction is a major drug …
The versatile relationships between eIF4E and eIF4E-interacting ...
2022年8月1日 · eIF4E is a highly conserved protein, and in silico studies have found that the evolutionary divergence of eukaryotes into hundreds of taxa following the Cambrian explosion …
Phosphorylation of the mRNA cap-binding protein eIF4E and cancer
Extracellular stimuli and mitogens stress activate components of the MAPK pathway including the ERK and p38 MAP kinases. In turn, MNK1 and MNK2 are activated by ERK and p38 MAP …