Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. [5] It is the only known protein to contain the unusual amino acid hypusine [N ε-(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps. [6]

2024年12月24日 · EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include Faundes-Banka Syndrome and Non-Specific Syndromic Intellectual Disability. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation.

2021年12月24日 · Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the isoform A2 is mainly expressed.

2024年12月1日 · Among these factors, eukaryotic translation initiation factor 5 A (eIF5A) emerges as a crucial translation factor with high evolutionary conservation. eIF5A is unique as it is the only protein in eukaryotic cells containing the hypusine modification.

2017年4月20日 · Using a combination of ribosome profiling and in vitro biochemistry, we report a much broader role for eIF5A in elongation and uncover a critical function for eIF5A in termination. Ribosome profiling of an eIF5A-depleted strain reveals a global elongation defect, with abundant ribosomes stalling at many sequences, not limited to proline stretches.

真核翻译起始因子5A（eukaryotic translation initiation factor 5A, eIF5A）是维持细胞活性必不可少的翻译因子，在进化上高度保守。 eIF5A是真核细胞中唯一含有羟腐胺赖氨酸（hypusine）的蛋白质，该翻译后修饰对eIF5A的活性至关重要。 1978年，人们首次鉴定出eIF5A，认为它在翻译起始阶段促进第1个肽键的形成。...

2020年12月28日 · 最新的研究数据表明，hypusinated化的EIF5A能够调节如自噬、衰老、多胺稳态、能量代谢等一系列关键的细胞进程，并在癌症中起作用。 然而，目前在临床前癌症模型中抑制EIF5A的作用、相关分子机制以及特定的翻译靶标仍知之甚少。

真核翻译起始因子5A（eukaryotic translation initiation factor 5A, eIF5A）是维持细胞活性必不可少的翻译因子,在进化上高度保守。 eIF5A是真核细胞中唯一含有羟腐胺赖氨酸（hypusine）的蛋白质,该翻译后修饰对eIF5A的活性至关重要。

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus.

2022年12月17日 · Here we show that the function of the elongation factor, eIF5a, is regulated dynamically in naïve CD8 + T cells upon activation by post-translational modification, whereupon it facilitates...