Targeting epiregulin in the treatment-damaged tumor ... - Nature
2022年10月6日 · EREG enhances glycolysis through activating EGFR signaling and its downstream glycolytic genes in tamoxifen-resistant BCa cells, whereby EREG is a direct target of miR-186-3p,...
EREG Gene - GeneCards | EREG Protein | EREG Antibody
2024年12月25日 · EREG (Epiregulin) is a Protein Coding gene. Diseases associated with EREG include Malignant Fibrous Histiocytoma and Squamous Blepharitis. Among its related pathways are Signaling by ERBB2 KD Mutants and Constitutive Signaling by Aberrant PI3K in Cancer.
Epiregulin is a dendritic cell–derived EGFR ligand that ... - AAAS
2022年12月9日 · Epidermal growth factor receptor (EGFR) is a member of the ERBB family of RTKs, is primarily expressed by epidermal keratinocytes, and is aberrantly activated in solid cancers, such as lung and breast (6).
Integrated analysis of EREG expression, a gene associated with …
2023年10月15日 · Our aim was to identify a new predictive marker of epiregulin (EREG) gene and explore its functional characteristics of CC and other cancer types. Differentially highly expressed genes were obtained from Gene Expression Omnibus (GEO) databases.
The Role of EREG/EGFR Pathway in Tumor Progression - PMC
Epiregulin (EREG) is one of the EGFR ligands and is low expressed in most normal tissues. Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer progression.
Epiregulin gene expression as a biomarker of benefit from
2013年12月12日 · Epidermal growth factor receptor ligand epiregulin (EREG) gene expression may further predict cetuximab benefit. Tumour samples from a phase III clinical trial of cetuximab plus best supportive...
The Role of EREG/EGFR Pathway in Tumor Progression
2021年11月27日 · Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer progression. Notably, a higher EREG expression level in CRC with wild-type Kirsten rat sarcoma viral oncogene homolog (KRAS) …
上皮调节素（EREG）基因 | MCE - MCE-生物活性分子大师
编码的蛋白质是表皮生长因子受体 (EGFR) 和结构相关的 erb-b2 受体酪氨酸激酶 4 (ERBB4) 的配体。 编码的蛋白质可能参与广泛的生物过程，包括炎症、伤口愈合、卵母细胞成熟和细胞增殖。 此外，编码的蛋白质可能促进各种人体组织癌症的进展。 [RefSeq 提供，2015 年 7 月] This gene encodes a secreted peptide hormone and member of …
表皮调节素的生理功能及其在消化系统肿瘤中的研究进展
表皮调节素（epiregulin，EREG）是表皮生长因子（EGF）超家族成员。 EGF家族包括EGF、转化生长因子-α、肝素结合EGF样生长因子（HB-EGF）、双向调节素（AREG）、β细胞调节素（BTC）、EREG、神经调节素及上皮细胞有丝分裂原共8个成员。
Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin …
2025年3月3日 · EREG-targeting antibody-drug conjugates demonstrate acceptable safety and robust therapeutic efficacy in RAS mutant and wild-type colorectal cancer,