The Role of EREG/EGFR Pathway in Tumor Progression
2021年11月27日 · Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer progression. Notably, a higher EREG expression level in CRC with wild-type Kirsten rat sarcoma viral oncogene homolog (KRAS) …
The Role of EREG/EGFR Pathway in Tumor Progression - PMC
The activated EREG/EGFR pathway regulates various cellular functions, including cancer cell proliferation, survival, metastasis, and angiogenesis, thereby conferring malignant tumor phenotypes . Clinicopathological and in vitro studies have revealed that EREG expression has prognostic importance in several human cancers.
The Role of EREG/EGFR Pathway in Tumor Progression - MDPI
2021年11月27日 · Novel strategies targeting EREG/EGFR, tumor-associated macrophages, and alternative activation oncoproteins are under development or undergoing clinical trials. In this review, we summarize the clinical outcomes of EREG expression and the interaction of …
Epiregulin is a dendritic cell-derived EGFR ligand that maintains …
Epiregulin is an EGFR ligand produced by DC3 dendritic cells that is essential for persistence of skin and lung fibrosis. Pathologic fibrosis is a common final outcome of most human chronic inflammatory diseases and has been estimated to underlie almost half of all human deaths in the developed world (1).
Cross-suppression of EGFR ligands - Nature
2012年4月10日 · In addition to the mutational status of KRAS, the epidermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG) might function as bona fide biomarkers of cetuximab...
EGFR-mediated local invasiveness and response to Cetuximab in …
2025年3月22日 · This invGRN comprises fDEGs and is activated by subtypes of EGFR-activity that are primarily governed by EGFR ligands AREG, EREG, and HBEGF in single tumor cells. These findings corroborated the importance of ligand availability [ 35 ] and describe for the first time an impactful heterogeneity of EGFR signaling at the level of single malignant ...
EREG/EGFR 通路在肿瘤进展中的作用,International ... - X-MOL
2021年11月27日 · 红细胞白血病病毒癌基因同源物 (ERBB) 配体对表皮生长因子受体 (EGFR/ERBB1) 的异常激活导致各种肿瘤恶性肿瘤，包括肺癌和结直肠癌 (CRC)。 上皮调节蛋白 (EREG) 是 EGFR 配体之一，在大多数正常组织中低表达。 各种癌症中升高的 EREG 主要激活 EGFR 信号通路并促进癌症进展。 值得注意的是，具有野生型 Kirsten 大鼠肉瘤病毒癌基因同源物 (KRAS) 的 CRC 中较高的 EREG 表达水平与更好的治疗效果有关。 相比之下，CRC中 …
Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin …
2025年3月3日 · The EGFR ligand epiregulin (EREG) is highly expressed in RAS wild-type (WT) and mutant colorectal cancer, with minimal expression in normal tissues, making it an attractive target for antibody–drug conjugate (ADC) development.
癌症基因突变合集——EGFR - 知乎 - 知乎专栏
表皮生长因子受体 （Epidermal Growth Factor Receptor, EGFR），也称为ErbB1/HER1，是EGFR家族的原型，由于其促进细胞增殖和对抗细胞凋亡的作用，常被视作原癌基因之一。1959年，Stanley Cohen与Rita Levi-Montalcini首次分离并确定了EGFR的作用，两人也因此获得1986年的 …
The Role of EREG/EGFR Pathway in Tumor Progression
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor malignancies, including lung cancer and colorectal cancer (CRC). Epiregulin (EREG) is one of the EGFR ligands and is low expressed in most normal tissues.