2025年2月8日 · Gene ID: 569014, updated on 8-Feb-2025. Predicted to enable glutathione hydrolase activity. Predicted to be involved in several processes, including glutathione catabolic process; peptide modification; and regulation of inflammatory response. Predicted to be active in plasma membrane.

2024年12月25日 · GGT1 (Gamma-Glutamyltransferase 1) is a Protein Coding gene. Diseases associated with GGT1 include Glutathionuria and Pancreatitis.Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Glutathione conjugation.Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity and glutathione hydrolase activity.

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γ-谷氨酰转肽酶 (GGT) 是一种位于细胞外膜上的酶，调节谷胱甘肽 (GSH) 的代谢，谷胱甘肽是细胞内最丰富的抗氧化剂硫醇。 GGT通过水解细胞外 GSH 并为细胞提供半胱氨酸的恢复，在氧化还原稳态的控制中发挥关键作用，而半胱氨酸是从头细胞内 GSH 和蛋白质生物合成所必需的。 因此，GGT的上调赋予细胞更强的抗 氧化应激 和快速生长的优势。 事实上，GGT 在炎症条件和各种人类肿瘤的进展中上调，并且与许多与氧化应激相关的生理疾病有关，例如心血管疾病和糖尿病 …

Predicted to enable glutathione hydrolase activity. Predicted to be involved in several processes, including glutathione catabolic process; peptide modification; and regulation of inflammatory response. Predicted to be active in plasma membrane. Human ortholog (s) of this gene implicated in gamma-glutamyl transpeptidase deficiency.

Here we systematically evaluated all human sequences related to GGT1 using genomic and cDNA database searches and identified thirteen genes belonging to the extended GGT family, of which at least six appear to be active.

由该基因编码的酶是一种 I 型 γ-谷氨酰转移酶，可催化谷胱甘肽的谷氨酰部分转移至多种氨基酸和二肽受体。 该酶由一条重链和一条轻链组成，它们源自单一的前体蛋白。 它在参与吸收和分泌的组织中表达，可能导致糖尿病和其他代谢紊乱的病因。 已识别出多个可变剪接变体。 20 号和 22 号染色体上存在许多相关基因，2 号、13 号和 22 号染色体上存在该基因的假定假基因。 [RefSeq 提供，2014 年 1 月]

2012年1月1日 · GGT1a and GGT1b exhibit a clear distinction in developmental expression with defined separation on PC2 in later (d8-12) stages of development. Developmental expression patterns of GGTL3a and GGTL3b are significantly divergent with distinct separation occurring within both principal components PC1 and PC2.

Gene ID: 105915321, updated on 20-Aug-2024. glutathione hydrolase 1 proenzyme, GGT1, gamma-glutamyltransferase 1 (GGT1, zgc:64172) Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer.

2013年12月1日 · In contrast, the GSH catabolism genes ggt1a, ggt1b, and gsr exhibited lower expression levels and few distinct features in the developmental profiles (Fig. 6 B). Genes involved in cysteine transport generally exhibited elevated expression levels between 12 and 48 hpf compared with earlier time points.