2024年12月25日 · MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Anus, Imperforate and Renal …

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase …

2016年1月1日 · Loss of HGK in T cells results in spontaneous systemic inflammation and type 2 diabetes in mice. HGK is also involved in cancer cell migration. To date, the phenotypes of …

2016年10月28日 · MAP4K4, also known as HGK (hematopoietic progenitor kinase/germinal center kinase-like kinase) or NIK (Nck interacting kinase, the mouse ortholog) is a …

2024年8月1日 · MAP4K4, also known as a HGK (human ortholog) and Nck-interacting kinase (NIK; mouse ortholog) (Delpire, 2009), is a serine/threonine protein kinase that serves as an …

We have identified a novel HGK (HPK-like/GCK-like kinase) gene product from a human SNB19 glioblastoma cell line library. The cDNA isolated was 3,798 bp long, encoding a protein of …

2021年6月10日 · Here, we have identified MAP4K4 as a relevant gene for metastasis in PCa. Our work shows that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded …

HGK promotes metastatic dissemination in prostate cancer. MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity. Targeted genomic CRISPR-Cas9 screen …

HGK (hepatocyte progenitor kinase-like/germinal center kinase-like kinase) is a member of the human STE20/mitogen-activated protein kinase kinase kinase kinase family of …

2014年5月26日 · HGK在卵巢癌、肝癌、肺癌、胰腺癌及前列腺癌等多种肿瘤中高表达，有可能成为肿瘤治疗的新作用靶点或预防某些肿瘤的发生。 本文就HGK在肿瘤中的研究进展及可能的 …

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases. MAP4Ks including MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, …

The gene view histogram is a graphical view of mutations across MAP4K4. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view …

Using degenerate polymerase chain reaction, we have isolated a human cDNA encoding a protein kinase homologous to STE20. This protein kinase, designated HPK/GCK-like kinase (HGK), …

AIM: To investigate the effects of RNA interference targeting hepatocyte progenitor kinase-like kinase (HGK) in the invasion and adhesion of hepatocellular carcinoma (HCC) cell line …

4 天之前 · Here we developed a random forest-based machine-learning pipeline, NeuRGI (Neutrophil Regulatory Gene Identifier), which utilized Positive-Unlabeled Learning (PU …

2015年12月21日 · Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4; also known as Nck-interacting kinase (NIK) and hepatocyte progenitor kinase-like/germinal centre kinase …

GLK过度表达T细胞的百分比与疾病活动性相关。 另外，HGK磷酸化并诱导TRAF2蛋白降解，从而导致静止T细胞中IL-6产生的负调控。 T细胞中HGK的丢失会导致小鼠自发性全身炎症和2型糖 …

1. Humans have three kallikrein genes: hGK-1, hRKALL (kinin-generating) and a gene encoding prostate specific antigen (PSA). 2. Using a gene-specific oligonucleotide, expression of hGK-1 …

HGK Antibody detects endogenous levels of total HGK protein. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide …

特异性： HGK Monoclonal Antibody detects endogenous levels of HGK protein. 组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 稀释： WB 1:500 - 1:2000. …