Heterogeneous nuclear ribonucleoprotein K (also protein K) is a protein that in humans is encoded by the HNRNPK gene. [5] It is found in the cell nucleus that binds to pre- messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles .

2024年12月25日 · HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) is a Protein Coding gene. Diseases associated with HNRNPK include Au-Kline Syndrome and Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To …

Heterogeneous ribonucleoprotein particle （异构核糖核蛋白颗粒）是一类存在于细胞核中的RNA与蛋白复合体，其主要存在在基因转录和随后的新合成的RNA的转录后调控过程中，参与核酸代谢过程。 在RNA合成加工过程中，由于结合在pre-mRNA上的蛋白发出了“pre-mRNA还没有完成加工过程”这样的一个信号，因此未完成加工的pre-mRNA不能运输到细胞质。 在RNA合成加工完成后，成熟的RNA通常会被非常快的从细胞核中运输出去，因此大多数核内的RNA结合蛋白是 …

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is highly expressed in non-small-cell lung cancer (NSCLC), and NSCLC with higher expression of hnRNP K are more frequently rated as high-grade tumors with poor outcome. hnRNP K increases microtubule stability via interacting with microtubule-associated protein 1B light chain and is associated ...

异质性核糖核蛋白 K： 该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNPs 是 RNA 结合蛋白，它们与异质核 RNA (hnRNA) 复合。 这些蛋白质与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。

2022年11月3日 · Here we demonstrate that the SCF Fbxo4 E3 ubiquitin ligase restricts the pro-oncogenic activity of hnRNPK via K63 linked polyubiquitylation, thus limiting its ability to bind target mRNA. We...

Since its original identification as a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, K protein has been found not only in the nucleus but also in the cytoplasm and mitochondria and is implicated in chromatin remodeling, transcription, splicing and …

The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process.

核内不均一性核糖核蛋白K (heterogeneous nuclear ribonucleoprotein K,hnRNP K)最早在hnRNA加工过程中被发现,属于hnRNP家族的一员。 研究表明hnRNPK的主要功能结构为3个引导DNA—RNA连接的KH域和一个独特的KI域。 hnRNP K不仅能够通过依赖CT元件的途径或不依赖CT元件的途径在转录水平上对基因表达进行调控,还能够通过自身的磷酸化,改变mRNA的翻译效率,以及调控基因翻译及转导胞内信号。 此外,hnRNP K与肿瘤发生和转移的关系也是近年来的研 …

2014年10月1日 · The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as …