2016年5月23日 · Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation.

2024年10月4日 · The HNRNP Q, also known as GRY-RBP, NSAP1, or SYNCRIP, has an acidic amino acid in the N-terminal region, which has three consecutive RRMs, and one of them contains a NLS at the C terminus, which...

2023年11月24日 · Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a family of RNA-binding proteins that bind to the primary transcripts of protein-coding genes. hnRNPs play a critical role in controlling the maturation, transport, and interaction of newly formed heterogeneous nuclear RNAs with other nuclear structures, which are essential for pre-mRNA proce...

2012年8月31日 · Under both normal and stress circumstances, hnRNP Q binds to the 5′UTR of mouse p53 mRNA and regulates translation efficiency, without affecting mRNA levels. In addition, we present evidence that...

2025年3月11日 · 异质核糖核蛋白 Q（heterogeneous ribonucleoprotein Q，hnRNP Q）是一种在细胞内发挥多种重要作用的蛋白质，以下是关于它的详细介绍： 基本结构与特点. 结构组成：hnRNP Q 属于 hnRNP 家族成员，包含多个结构域，具有 RNA 结合结构域，能够特异性地与 RNA 结合，还含有一些其他功能结构域，如富含甘氨酸结构域等，这些结构域对于其功能的发挥具有重要作用。 蛋白特性：通常以单体或多聚体的形式存在于细胞内，相对分子质量一般在 …

Using affinity chromatography, we identified several SMN RNA-associating proteins in mouse testis and human HeLa cells, including hnRNP Q. The major hnRNP Q isoform, Q1, directly bound SMN exon 7 in the vicinity of nucleotide +6. Overexpression of hnRNP Q1 promoted the inclusion of exon 7 in SMN2, probably by activating the use of its upstream ...

Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and …

2019年2月4日 · Here, we unambiguously demonstrate that the fmr1 gene, which encodes FMRP, exploits both IRES-mediated translation and canonical cap-dependent translation. Furthermore, we find that heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) acts as an IRES-transacting factor (ITAF) for IRES-mediated fmr1 translation in neurons.

Nonetheless, our study sheds light on the distinctive functions of hnRNP Q and hnRNP R in human neuronal cells and, in general, provides insights on the involvement of the hnRNP family in controlling neuronal and inflammatory pathways, strengthening the hypothesis that differential expression of these RBPs could play an essential role in ...

2019年5月10日 · In this study, we determine that an RNA-binding protein, hnRNP Q, has a critical role in translational control of Bmal1 mRNA. We also show that hnRNP Q binds to a specific region of the Bmal1 mRNA 5′ UTR and negatively regulates Bmal1 mRNA translation.