2024年12月25日 · IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) is a Protein Coding gene. Diseases associated with IFIT1 include Microphthalmia With Limb Anomalies and Chilblain Lupus. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

摘要: IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族 (ISGs)成员，主要存在于细胞质，其表达受干扰素 (IFN)、多种病毒和某些病原体相关分子模式的调节，具有抗病毒、抗炎等作用。 IFIT1的抗病毒作用可通过多种机制和途径发挥，同时部分病毒也进化出独特的机制逃避宿主IFIT1的限制作用，从而对抗机体抗病毒免疫。 在许多炎症性疾病中，IFIT1也显示出其独特的抗炎作用。 该文就IFIT1的抗炎和抗病毒作用与相关机制作一综述，为进一步研究相关疾病的治 …

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene. [4] [5] [6]

IFIT proteins (Interferon Induced proteins with tetratricopeptide repeats) are produced in the human body and are supposed to confer immunity against viral infections. These proteins are generally produced during viral infection by interferon ( IFN ) treatment as well as during pathogen recognition ( Pathogen associated molecular pattern ...

干扰素诱导蛋白与四肽重复 1： 该基因编码一种含有四肽重复序列的蛋白质，最初被鉴定为在干扰素处理后被诱导产生。 编码的蛋白质可以抑制病毒复制和翻译起始。

2012年12月14日 · IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — contribute to...

2011年6月5日 · By an affinity proteomics approach with PPP-RNA as the 'bait', we found that the antiviral protein IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) mediated binding of a...

IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. You might find these chapters and articles relevant to this topic.

2025年1月4日 · HIV-1 Vpr antagonizes IFIT1 (ISG56) mRNA induction in TZM-bl STING cells (TZM-bl cells engineered to express TMEM173 (STING)); IFIT1 is involved in viral recognition innate sensing within cell PubMed vpr

2025年1月16日 · The Ifit1 gene is a key component in the body’s defense against viral infections, playing a role in innate immunity as an early responder to pathogenic threats. Understanding its function and interaction with viruses can help researchers develop strategies to …