2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced...

Inflammatory signals, changes in levels of reactive oxygen species, ultraviolet radiation, protein synthesis inhibitors, and a variety of stress stimuli can activate JNK. One way this activation may occur is through disruption of the conformation of sensitive protein phosphatase enzymes; specific phosphatases normally inhibit the activity of ...

JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein kinase， 丝裂原活化蛋白激酶） 信号通路 的另一亚类。 JNK 信号转导通路 是 MAPK 通路的一重要分支，它在 细胞周期 、生殖、凋亡和 细胞应激 等多种生理和 病理过程 中起重要作用。 JNK信号转导通路是1991年发现的一类MAPK通路。 JNK 蛋白激酶 由3个基因编码，jnk 1和jnk 2基因在全 …

应激活化蛋白激酶 (sapk)/jun 氨基末端激酶 (jnk) 是 mapk 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 gpcr 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。

2007年5月1日 · c-Jun N-terminal protein kinases (JNK), also known as stress-activated protein kinases, were originally identified by their ability to phosphorylate the N-terminal of...

2001年11月20日 · Our studies reveal a novel aspect of the regulation of Jnk-signaling, a DSP that may function in the activation of Jnk without effect on Erk and p38 MAPKs. Therefore, it will be exciting to see whether, with continued investigation, JSP-1 may also be considered as a target for therapeutic intervention in human disease.

2008年10月20日 · JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of...

2025年3月13日 · There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB (Figure 2).

6 天之前 · CARD11 is a critically important signaling hub and scaffold protein that controls T cell activation by linking TCR engagement to the activation of the nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), mechanistic target of rapamycin (mTOR), and Akt pathways (13, 14).Mice deficient in CARD11 exhibit defects in T cell activation …

2024年8月1日 · JNKs are activated through phosphorylation by upstream MAPK Kinases (e.g., MKK4/7), which are themselves activated by MAPK Kinase Kinases (MAP3K). Once activated, JNK translocates to the nucleus to modulate the expression of various transcription factors (e.g., ATF-2, c-Jun) and nuclear hormone receptors (Fig. 1) [1, 3, 5, 6].