Inflammatory signals, changes in levels of reactive oxygen species, ultraviolet radiation, protein synthesis inhibitors, and a variety of stress stimuli can activate JNK. One way this activation …

JNK activators, or c-Jun N-terminal kinase activators, are essential tools in the study of cellular signaling pathways. JNK is a subgroup of the mitogen-activated protein kinase (MAPK) family, …

2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF …

2008年11月25日 · Here, we report the characterization of the JNK-interacting protein 3 (JIP-3) scaffolding protein as an interacting partner of Rho-associated kinase 1 (ROCK1), as …

In this review, we will go over JNK signaling and focus on (1) the evidence of JNK activation in inflamed joints, (2) how the activation of the JNK signaling pathway is immunologically …

2001年11月20日 · Our studies reveal a novel aspect of the regulation of Jnk-signaling, a DSP that may function in the activation of Jnk without effect on Erk and p38 MAPKs. Therefore, it will be …

5 天之前 · There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active …

2024年10月7日 · JNK signaling plays an instrumental part in orchestrating this process, acting as a mediator that can either promote or inhibit apoptosis depending on the cellular context. …

2020年5月5日 · Here, we report that atRAL activates c-Jun N-terminal kinase (JNK) signaling at least partially through reactive oxygen species production, which promoted mitochondria …

3 天之前 · CARD11 is a critically important signaling hub and scaffold protein that controls T cell activation by linking TCR engagement to the activation of the nuclear factor κB (NF-κB), c-Jun …