c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the …

2024年12月25日 · Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling …

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, …

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and …

JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein …

2006年12月5日 · JNK are multifunctional kinases involved in many physiological processes. The JNK pathway has been shown to play a major role in apoptosis in many cell death paradigms …

JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun. As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress …

2018年3月6日 · To test whether the cJUN NH 2 -terminal kinase (JNK) signal transduction pathway contributes to involution, we established mice with JNK deficiency in the mammary …

2016年1月11日 · Three genes, namely jnk1 (MAPK8), jnk2 (MAPK9), and jnk3 (MAPK10), encode for 10 different splice variants with molecular weights of 46 and 55 kDa (Davis, 2000). …

4 天之前 · JNK can promote apoptosis by increasing the expression of pro-apoptotic genes through the transactivation of c-Jun/AP1-dependent or p53/73 protein-dependent …