JNK, by phosphorylation, modifies the activity of numerous proteins that reside at the mitochondria or act in the nucleus. Downstream molecules that are activated by JNK include c-Jun , ATF2 , ELK1 , SMAD4 , p53 and HSF1 .

JNK，（c-Jun氨基末端激酶，c-Jun N-terminal kinase）又被称为应激活化蛋白激酶(stress-activated protein kinase, SAPK)，是哺乳类细胞中MAPK（mitogen-activated protein kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。

2016年7月27日 · The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including neuronal functions, immunological actions, an …

2020年9月30日 · JNK proteins can associate with scaffold proteins, JIP (JNK interacting proteins) as well as upstream kinases following activation. They modify the activity of proteins at the mitochondria or...

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that …

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。

2005年1月1日 · However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or...

2016年1月11日 · The JNK family of protein kinases is one of the three identified families of mitogen activated protein (MAP) kinases. Three genes, namely jnk1 (MAPK8), jnk2 (MAPK9), and jnk3 (MAPK10), encode for 10 different splice variants with molecular weights of 46 and 55 kDa ( …

JNK又被称为应激活化蛋白激酶（stress-activated protein kinase, SAPK），是哺乳类细胞中MAPK（Mitogen-activated Protein Kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。MAPK-JNK通路可由各种不同环境应激、炎症细胞因子、生长因子以及CPCR激动剂激活。

2014年4月17日 · JUN amino-terminal kinases (JNKs) are dominant regulators of protein phosphorylation in the nervous system. JNKs serve critical functions in developing brain, being required for...