Nodal antagonists regulate formation of the anteroposterior ... - Nature
2004年3月7日 · Lefty2 expression was also examined with a Lefty2–lacZ transgene (p, q) in which LacZ expression is driven by the upstream 5.5-kb region of the Lefty2 gene 17.
Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of …
The lefty2 mutant phenotype was partially suppressed by heterozygosity for nodal, suggesting antagonistic effects of the two proteins. In addition, we found that Lefty2 and Antivin act as …
Both Nodal signalling and stochasticity select for prospective distal ...
2017年11月14日 · Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells. Ablation of L1epi or L1dve cells triggered Lefty1 expression in a subset …
Left–right patterning of the mouse lateral plate requires nodal ...
2003年4月1日 · The lack of Nodal expression in left LPM of Nodalneo/neo embryos was further confirmed with the use of a Lefty2 ASE-LacZ transgene that is a sensitive indicator of Nodal …
Diffusion of Nodal Signaling Activity in the Absence of the …
2000年12月15日 · The role of Lefty2 in left–right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects …
Two-Step Regulation of Left–Right Asymmetric Expression of
2001年1月1日 · Pitx2 is left–right (L–R) asymmetrically expressed initially in the lateral plate and later in primordial visceral organs. The transcriptional regulatory mechanisms that underlie …
Mechanism for generation of left isomerism in Ccdc40 mutant …
2017年2月9日 · We propose a model to explain how left isomerism arises in a proportion of Ccdc40lnks mutants. We postulate that with defective motile cilia, Cerl2 expression remains …
Inhibition of Nodal signalling by Lefty mediated through …
2002年4月19日 · The phenotype of lefty2 mutant mice and the genetic interaction between lefty2 and nodal suggest that Lefty antagonizes Nodal activity. Our biochemical data now establish …
Nodal signaling induces the midline barrier by activating
2003年5月1日 · Our results indicate that the leftsided expression of Nodal in LPM is initiated by Nodal produced in the node, and that Lefty1 expression at the midline is induced by Nodal …
Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC ...
2004年2月17日 · We report that the TGFβ signaling antagonist Lefty also acts through an EGF-CFC-dependent mechanism. Lefty inhibits Nodal and Vg1 signaling, but not Activin signaling. …
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