Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. [5] [6] mGluR2 is a G protein-coupled receptor (GPCR) that couples with the Gi alpha subunit. [7]

2024年6月7日 · In this study, we found two membrane proteins––potassium calcium-activated channel subfamily M alpha 1 (KCa1.1) encoded by KCNMA1 and metabotropic glutamate receptor 2 (mGluR2) encoded by GRM2...

2021年12月14日 · Here, we found that metabotropic glutamate receptor subtype 2 (mGluR2) is an internalization factor for SARS-CoV-2. Our results show that mGluR2 directly interacts with the SARS-CoV-2 spike...

通过解析mGluR2跨膜结构域与反向别构调节因子（negative allosteric modulator，NAM）的复合物三维结构，从分子水平分析受体与配体的结合机制，能够为设计特异性强、效力高的药物提供结构基础。

2024年6月8日 · 这项最新研究发现，信号转导分子、跨膜糖蛋白代谢型谷氨酸受体2（mGluR2）与流感病毒的血凝素蛋白互作，启动流感病毒的网格蛋白介导的内吞（clathrin-mediated endocytosis，CME）。mGluR2可溶性抗体封闭后，流感病毒感染细胞的效率大大下降。

2024年6月29日 · 作者进一步使用针对 mGluR2 胞外结构域的单克隆抗体 (mGluR2-ma) 进行了抗体阻断试验，发现 mGluR2-ma 以剂量依赖性方式抑制 H1N1 病毒感染 (图 3g、h)。 mGluR2 不影响腺病毒 5 型或转铁蛋白的内吞作用（图 3f、h、i），尽管它们也通过 CME 进入细胞，这表明 mGluR2 介导的 ...

In addition to schizophrenia and anxiety, ligands at group II mGluRs have also been suggested as therapeutic directions for other CNS disorders, including mGluR2 and mGluR3 agonists and mGluR2 PAMs for treatment of pain, addictive disorders, depression, and …

In this review, we discuss what is currently known regarding the contribution of mGluR2 and mGluR3 to the pathophysiology of some neurodegenerative and neuropsychiatric diseases including Amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Parkinson's diseases, schizophrenia and depression as well as drug addiction.

2018年7月20日 · Here, we identified metabotropic glutamate receptor subtype 2 (mGluR2) as a novel cellular RABV receptor for host cell entry. mGluR2 directly interacts with RABV G protein and both proteins are internalized together. Our findings may open a door to explore the fundamental molecular mechanisms for rabies neuropathogenesis.

2021年6月16日 · Here we report four cryo-electron microscopy structures of the human mGlu subtypes mGlu2 and mGlu7, including inactive mGlu2 and mGlu7 homodimers; mGlu2 homodimer bound to an agonist and a positive...