In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. The 3′-UTR often contains regulatory regions that post-transcriptionally influence gene expression.

2019年10月1日 · This review summarizes both 3' UTR functions-the regulation of mRNA and protein-based processes-and highlights how each 3' UTR function was discovered with a focus on experimental approaches used and the concepts that were learned.

If it is found on the 5' side, it is called the 5' UTR (or leader sequence), or if it is found on the 3' side, it is called the 3' UTR (or trailer sequence). mRNA is RNA that carries information from DNA to the ribosome, the site of protein synthesis (translation) within a cell.

3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In addition, 3′ UTRs can establish 3′ UTR-mediated protein–protein interactions ...

Here we review available information about human 3′ UTRs, known classes of 3′ UTR cis elements, evidence that supports the importance of 3′ UTRs in lung disease, and recent progress toward transcriptome-wide analysis of 3′ UTRs.

2023年8月15日 · Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining...

Genomic information stored in the DNA is transcribed to the mRNA and translated to proteins. The 3′ untranslated regions (3′UTRs) of the mRNA serve pivotal roles in post-transcriptional gene expression, regulating mRNA stability, translation, and localization.

2003年8月1日 · Adding to the complexity, 3′ untranslated regions (UTRs) often contain several regulatory elements that govern the spatial and temporal expression of an mRNA. Furthermore, several...

2025年2月21日 · These longer 3′ UTRs tend to remain in the neuronal soma, whereas shorter UTR isoforms localize to the synapse. In cultured pumilio mutant neurons, axon outgrowth defects are accompanied by mRNA isoform mislocalization, and proteins encoded by these Pumilio target mRNAs display excessive abundance at synaptic boutons. Our study identifies an ...

2023年6月6日 · The 3’ untranslated region (3’UTR) of mRNA plays a key role in post-transcriptional regulation of gene expression. Most eukaryotic protein-coding genes express 3’UTR isoforms owing to alternative cleavage and polyadenylation (APA).