mTORC2 Is the Major Second Layer Kinase Negatively Regulating …
2022年8月24日 · Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of …
Interplay between FOXO, TOR, and Akt - ScienceDirect
2011年11月1日 · Akt inhibits FOXO through direct phosphorylation, and indirectly activates mTORC1, which in turn elevates protein synthesis. mTORC1 and its downstream effector, …
FoxOs inhibit mTORC1 and activate Akt by inducing the ... - PubMed
2010年4月20日 · Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms. First, FoxO1 induces Sestrin3 (Sesn3) gene expression. Sesn3, in turn, inhibits …
FoxOs Inhibit mTORC1 and Activate Akt by Inducing the …
2010年4月20日 · Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms. First, FoxO1 induces Sestrin3 (Sesn3) gene expression. Sesn3, in turn, inhibits …
mTORC2: The other mTOR in autophagy regulation
2021年7月12日 · In addition to a role for mTORC2 as a regulator of FOXO through AKT-induced phosphorylation and cytoplasmic localization, mTORC2 has been shown to directly interact …
AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells ... - PubMed
2019年3月1日 · AZD8055 treatment partially reversed FOXO1 inactivation downstream of BCR crosslinking, significantly inhibiting FOXO1 T24 phosphorylation in an mTORC2-AKT …
A phase II trial of mTORC1/2 inhibition in STK11 deficient non …
4 天之前 · Dual mTORC1/2 inhibition may be more effective than mTORC1 inhibition alone. mTORC2 is a central node driving enhanced ... phosphorylation of targets including the pro …
mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma …
2013年11月5日 · We show that mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn …
The mTOR Pathway Controls Cell Proliferation by Regulating the
2014年2月18日 · These results suggest that inactivation of mTORC1 strongly activated Akt via activation of mTORC2 and abrogation of the negative-feedback inhibition mediated by Grb10. …
mTORC2 Is the Major Second Layer Kinase Negatively Regulating …
Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of cancer and healthy …