Hedgehog-Interacting Protein is a multimodal antagonist of …
2021年12月9日 · Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity,...
The structure of SHH in complex with HHIP reveals a recognition …
2009年6月28日 · Hedgehog-interacting protein (Hhip) is a surface receptor antagonist that is equipotent against all three mammalian Hh homologs. The crystal structures of human HHIP...
Hedgehog interacting protein (HHIP) represses airway ... - Nature
2021年4月27日 · Our results show HHIP inhibited aerobic glycolysis and represses cell proliferation in COPD-derived ASMCs. Notably, knockdown of HHIP in normal ASMCs …
HHIP蛋白的功能与信号调控—艾普蒂生物 - 搜狐
2024年9月26日 · HHIP蛋白是Hedgehog信号通路中的重要负调控因子，通过直接与Hh配体结合，抑制信号通路的过度激活。 HHIP在胚胎 发育、组织再生、纤维化等生理和病理过程中扮演 …
HHIP Gene - GeneCards | HHIP Protein | HHIP Antibody
2024年12月25日 · The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. …
刺猬相互作用蛋白（HHIP）基因 | MCE - MCE-生物活性分子 ...
The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single …
Shh-mediated degradation of Hhip allows cell autonomous and …
Here we show that while Hhip is able to leave its sites of synthesis to inhibit Shh non-cell autonomously, activation of Smoothened (Smo) drastically increases Hhip internalization and …
Canagliflozin inhibits hedgehog interacting protein (Hhip) …
2025年3月1日 · Renal hedgehog interacting protein (Hhip) activates sodium-glucose cotransporter 2 (Sglt2) expression and promotes tubular senescence in murine diabetic kidney …
Hedgehog-Interacting Protein is a multimodal antagonist of …
2021年12月9日 · Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity, …
Hhip inhibits proliferation and promotes differentiation of …
2019年6月18日 · Recombinant Hedgehog interacting protein (rHhip) could down-regulate cell cycle related genes and cell numbers in S phage to inhibit cell proliferation. Moreover, rHhip …
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