2020年10月14日 · We tracked hallmark features of dystrophy on a cellular and whole muscle level by isolating individual muscle fibers and clearing whole muscles of WT and mdx mice from 2 weeks to 2 years of...

2020年8月21日 · Duchenne muscular dystrophy (DMD) is an X-linked, lethal muscle degenerative disease caused by loss of dystrophin protein. DMD has no cure and few treatment options.

C57BL/10ScSn-Dmdmdx/J mice (001801), commonly called mdx, are the most published model of Duchenne’s muscular dystrophy. The mice carry a loss-of-function mutation in the dystrophin (Dmd) gene, and homozygotes show progressive cycles of muscle degeneration and regeneration starting at about three weeks of age.

2020年8月21日 · Duchenne muscular dystrophy (DMD) is an X-linked, lethal muscle degenerative disease caused by loss of dystrophin protein. DMD has no cure and few treatment options. Preclinical efforts to identify potential DMD therapeutics have been hampered by lack of a small animal model that recapitulates key f …

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly promising therapeutic strategy is to replace or repair the defective dystrophin gene by gene therapy.

2018年2月16日 · Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with cardiorespiratory failure occurring by the third decade of life. There is no specific treatment...

D2.B10-Dmdmdx/J (013141) is a newer JAX strain created by backcrossing 001801 mice onto the DBA/2J background. This new strain better recapitulates several of the human characteristics of DMD myopathy (reduced lower hind limb muscle weight, atrophied myofibers, increased fibrosis and inflammation, and muscle weakness) when compared to B10-mdx mice.

Physiological markers of muscle function and damage (i.e., range of motion, delayed onset muscle soreness, isometric, concentric and eccentric peak torque) were assessed prior to and 1–3 and 5...

JAX performs efficacy studies on mouse models for these diseases: C57BL10.mdx and D2.mdx for DMD, dyW for CMD1A, and A/J for dysferlinopathy. Additional mouse mutants are available for studies.

Moxidectin (MXD), an antiparasitic drug, is effective for a variety of external and internal parasites in companion and farm animals. This study aimed to calculate the withdrawal period by investigating the residue depletion of MXD in swine edible tissues after pouring at the dosage of 2.5 mg/kg B.W …