2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor protein. Nm23-H1 prolongs...

NM23-H1 inhibits tumor cell proliferation by phosphorylating the MAPK scaffold KSR resulting in suppression of MAPK signalling. Overexpression of NM23-H1 was shown to promote metastatic dormancy in a pulmonary metastasis mouse model.

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and protein degradation, which significantly modulate its anti-metastatic function.

2013年10月1日 · By this approach, we identified the actin-severing protein Gelsolin as binding partner for Nm23-H1, verifying their interaction by coimmunoprecipitation in 4T1 cells as well as in human MCF7, MDA-MB-231T, and MDA-MB-435 breast cancer cells.

2021年3月1日 · As a multi-faceted protein, NM23-H1 possesses nucleoside diphosphate kinase (NDPK) activity, histidine kinase (HPK)activity, and exonuclease activity on DNA as well as protein scaffold. The dual role of NM23 as a pro or anti-metastatic gene adds a …

2011年1月1日 · The metastasis suppressor NM23-H1 possesses three enzymatic activities in vitro, a nucleoside diphosphate kinase (NDPK), a protein histidine kinase, and a more recently characterized 3’–5’ exonuclease.

In humans, the eight NM23 genes that have been identified to date, NM23-H1, NM23-H2, NM23-H3, NM23-H4, NM23-H5, NM23-H6, NM23-H7, and NM23-H8, encode NDP kinases or homologous isoforms . However, although NM23-H1 was initially identified as a putative metastasis suppressor, its enzymatic activity does not appear to be responsible for its ...

2011年10月10日 · Tumor virus encoded oncoproteins can effectively modulate cancer metastasis by regulating Nm23-H1 associated activities. Following infection, tumor viruses encoded oncoproteins (EBV EBNA3C and EBNA1; KSHV LANA and HPV E7) target multiple cellular pathways, including metastasis.

2006年6月1日 · The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas.

2021年3月1日 · The tumor cells have evolved multiple ways to regulate the expression and function of NM23-H1 during tumorigenesis and metastasis, partially addressing the inconsistency between NM23-H1 protein level and metastatic propensity in certain cancer cells.