2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor …

NM23-H1 inhibits tumor cell proliferation by phosphorylating the MAPK scaffold KSR resulting in suppression of MAPK signalling. Overexpression of NM23-H1 was shown to promote …

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and …

2013年10月1日 · By this approach, we identified the actin-severing protein Gelsolin as binding partner for Nm23-H1, verifying their interaction by coimmunoprecipitation in 4T1 cells as well …

2021年3月1日 · As a multi-faceted protein, NM23-H1 possesses nucleoside diphosphate kinase (NDPK) activity, histidine kinase (HPK)activity, and exonuclease activity on DNA as well as …

2011年1月1日 · The metastasis suppressor NM23-H1 possesses three enzymatic activities in vitro, a nucleoside diphosphate kinase (NDPK), a protein histidine kinase, and a more recently …

In humans, the eight NM23 genes that have been identified to date, NM23-H1, NM23-H2, NM23-H3, NM23-H4, NM23-H5, NM23-H6, NM23-H7, and NM23-H8, encode NDP kinases or …

2011年10月10日 · Tumor virus encoded oncoproteins can effectively modulate cancer metastasis by regulating Nm23-H1 associated activities. Following infection, tumor viruses encoded …

2006年6月1日 · The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the …

2021年3月1日 · The tumor cells have evolved multiple ways to regulate the expression and function of NM23-H1 during tumorigenesis and metastasis, partially addressing the …