OxLDL was demonstrated to be involved in the foam cell formation and stimulation of the immune response. OxLDL acts through various mechanisms, among which are interaction with scavenger receptors, modulating inflammation-related molecular pathways, including miRNA regulation and NLRP3 inflammasome activation.

Measurement of oxidized LDL (oxLDL) has been incorporated into clinical practice in the diagnosis and treatment of lipid disorders (such as diabetes mellitus), atherosclerosis, and various liver and renal diseases, especially as it pertains to the evaluation of oxidative stress.

YEASEN提供的人源氧化低密度脂蛋白（Human Oxidized Low Density Lipoprotein，Ox-LDL），是由过度铜离子介导人血浆来源的LDL进行的氧化修饰。 新鲜血浆经检测为HCV，HBsAg和HIV阴性。 本产品为无菌包装，可以直接稀释使用。 本Ox-LDL广泛用于脂质代谢的研究。 另外我们还提供High Ox-LDL（货号：20608ES03）可产生明显的氧化应激，能够用来诱导细胞凋亡，并建立细胞损伤模型。 除提供Ox-LDL，我们还提供人源乙酰化LDL（Ac …

氧化修饰低密度脂蛋白（OX－LDL）是低密度脂蛋白（LDL）内大量多价不饱和脂肪酸在过量自由基及其他致氧因素作用下发生过氧化反应，最后产生丙二醛（MDA），MDA与LDL载脂蛋白B（APOB）中的赖氨酸残基结合发生化学修饰的产物。 大量的基础及临床研究资料证明，OX-LDL引发的一系列病理生理改变是导致动脉粥样硬化形成的关键，与动脉粥样硬化患者病情严重程度密切相关。 OX-LDL具有很快被巨噬细胞和平滑肌细胞吞噬的生物学特性，是形成泡沫细胞 …

Oxidized LDL (OxLDL) and the fluorescently labeled DiI-OxLDL are oxidized forms of the human low-density lipoprotein (LDL). LDL is an important lipid-protein complex that is involved in lipid transport and contributes to atherosclerosis.

Oxidized LDL (OxLDL) What is OxLDL? Think of OxLDL as damaged LDL. LDL is often called the “bad” cholesterol, because high levels of LDL can lead to heart disease and heart attacks. Damaged or oxidized LDL is even more likely to invade the walls of your blood vessels and increases your risk of heart disease. Why check my OxLDL level?

氧化低密度脂蛋白是指低密度脂蛋白（low-density lipoprotein，LDL）内大量不饱和脂肪酸在过量自由基或其他致氧因素作用下发生过氧化反应，最后产生丙二醛（malondialdehyde，MDA），MDA与LDL表面的载脂蛋白（apolipoprotein apo）B结合发生化学修饰的产物。 LDL是一种运载胆固醇进入外周组织细胞的球形脂蛋白颗粒，直径约22 nm，核心包括1 500个胆固醇酯、800个磷脂和500个游离胆固醇分子；LDL外层apoB100。 如 图1所示， …

Oxidized low-density lipoprotein (OxLDL) is a modified form of LDL that has undergone oxidative changes, significantly altering its biochemical properties and physiological functions [7]. However, when LDL undergoes oxidation, it contributes to the development of atherosclerosis, a leading cause of cardiovascular diseases [8, 9].

The expression of CD36 and Lectin-like oxLDL receptor 1 (LOX-1) in macrophages were detected by Western blotting to investigate the role of TLR4 in the expression of oxLDL-related receptors....

2021年1月11日 · Oxidized LDL can trigger inflammation through the activation of macrophages and other cells. After all, oxidized LDL is still a promising object for further investigations that have the potential to clarify the unknown parts of the atherogenic process. In this review, we discuss the role of oxLDL in atherosclerosis development on different levels.