第一个发现的细胞内第二信号——cAMP信号通路（下） - 知乎
对CD8+和Vδ1+T细胞之间差异表达基因进行pathway富集分析，可以富集到cAMP-PKA和ERK (MAPK) 通路。 这里我们可以看到， 作者采用了不同组学、不同分析策略，来锁定目标基因、 …
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · ERK1 and ERK2 are part of a family of structurally related kinases, called mitogen-activated protein kinases (MAPKs), the signalling mechanism of which depends on an …
Enhanced kinase translocation reporters for simultaneous real …
2025年3月1日 · To address these limitations, we developed enhanced KTRs (eKTRs) for PKA and extracellular signal–regulated kinase (ERK) by (i) increasing KTR size, which reduces the …
Cross Talk between ERK and PKA Is Required for Ca
1998年10月1日 · We propose that PKA is required for Ca 2+-stimulated CREB-mediated transcription, because PKA activity is necessary for the nuclear translocation of ERK and …
Non-canonical β-adrenergic activation of ERK at endosomes
2022年10月26日 · Here we investigated how spatially organized β 2 -adrenergic receptor (β 2 AR) signalling controls ERK. Using subcellularly targeted ERK activity biosensors 5, we show that …
Multiplexing PKA and ERK1&2 kinases FRET biosensors in living …
2017年1月20日 · PKA scaffold proteins such as the A-kinase anchoring proteins (AKAP) together with that of ERK1&2, the kinase suppressor of Ras (KSR), can enhance cAMP control of the …
快速了解ERK/MAPK信号通路？ - 知乎专栏
在真核细胞中已经确定了以下四条MAPK级联途径：ERK、 JNK 、 p38 MAPK 和ERK5信号转导途径。 今天我们来快速了解一下ERK/MAPK信号通路。 ERK是一种丝氨酸/苏氨酸蛋白激酶，是 …
The road to ERK activation: Do neurons take alternate routes?
PKA regulates ERK activation by phosphorylation of several proteins in the ERK activation pathway, including Src, Rap1GDP, C-Raf and B-Raf, and can either decrease or increase …
Enhanced kinase translocation reporters for simultaneous real …
2024年9月30日 · To address these limitations, we developed enhanced KTRs (eKTRs) for protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) that display high sensitivity, …
Cross Talk between ERK and PKA Is Required for Ca
Here, we report that extracellular signal–related protein kinase (ERK) signaling is obligatory for Ca 2+ -stimulated transcription in PC12 cells and hippocampal neurons. The sequential activation …