In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

蛋白激酶A（protein kinase A，PKA）又称依赖于cAMP的蛋白激酶A（cyclic-AMP dependent protein kinase A），是一种结构最简单、生化特性最清楚的蛋白激酶。 PKA全酶分子是由四个亚基组成的四聚体，其中两个是调节亚基（regulatory subunit，简称R亚基），另两个是催化亚基 ...

PKA是cAMP依赖的蛋白激酶 (cyclic-AMP dependent protein kinase A)， 一般认为, 真核细胞内大部分cAMP的作用都是通过活化PKA，从而使其底物蛋白发生磷酸化而实现的。 PKA全酶分子是由四个亚基组成的四聚体,其中两个是调节亚基 (regulatory subunit, 简称R亚基)，另两个是催化亚基 (catalytic subunit, 简称C亚基)。 在大多数哺乳类细胞中，至少有两类蛋白激酶A，一类存在于胞质溶胶 (I型)， 另一类结合在质膜、核膜和微管上 (II型)。 PKA全酶没有活性，在没有cAMP时， …

又称PKA系统(protein kinase A system, PKA)，是环核苷酸系统的一种。 在这个系统中，细胞外信号与相应受体结合，通过调节细胞内第二信使cAMP的水平而引起反应的信号通路。

2004年3月11日 · Protein kinases play a critical role in the integration of signaling networks in eukaryotic cells. cAMP-dependent protein kinase (PKA) serves as a prototype for this large and highly diverse enzyme family.

Protein kinase A (PKA) is a key regulator of cellular functions by selectively phosphorylating numerous substrates, including ion channels, enzymes, and transcription factors. It has long served as a model system for understanding the eukaryotic kinases.

Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress signals, most notably catecholamines secreted by the sympathetic ...

Protein kinase A (PKA) is a 3′-5′-cyclic adenosine monophosphate (cAMP)-dependent kinase that is at the center of diverse biological functions in numerous systems. Inactive PKA is composed of two catalytic (PKA-C) and two regulatory (PKA-R) subunits.

Cyclic AMP-dependent protein kinase A (PKA) is a ubiquitous enzymatic complex that is involved in a broad spectrum of intracellular receptor signaling. The activity of PKA depends on A-kinase anchoring proteins (AKAPs) that attach to PKAs close to their substrates to control signaling.

2004年3月11日 · Protein kinases play a critical role in the integration of signaling networks in eukaryotic cells. cAMP-dependent protein kinase (PKA) serves as a prototype for this large and highly diverse enzyme family. The catalytic subunit of PKA provides the best example of how a protein kinase recognizes its …